ABSTRACT
A 61-year-old female patient presented a nodular lesion located in the right buccal mucosa with a 3-month evolution. Clinical hypotheses of salivary duct cyst and mucocele were proposed, and the patient underwent excisional biopsy. Microscopically, a well-circumscribed and encapsulated lymphoid aggregate fragment was observed, characterized by layers of well-differentiated small lymphocytes and collections of reactive lymphoblasts. These findings, associated with immunohistochemistry, established the diagnosis of follicular lymphoid hyperplasia. Currently, the patient is well, under follow-up after six months.
Key words:
lymphoid tissue; pseudolymphoma; diagnosis differential; lymphoma; oral medicine
A) intraoral clinical aspect; B) ultrasonography presenting cyst with heterogeneous content measuring 0.6 × 0.5 × 0.5 cm, at a distance of 1.2 cm from the skin.
A) microscopic aspect of the surgical specimen showing a well-circumscribed encapsulated lymphoid lesion; B) capsule of dense fibrous connective tissue and lymphocytes with monotonous morphology; C) double population of lymphocytes (small well-differentiated lymphocytes, and collections of reactive lymphoblasts); D) sprouting of small vessels and endothelial cells.FLH: follicular lymphoid hyperplasia; HE: hematoxylin and eosin.
A) CD10 (-) identifies lymphoid progenitor cells, germinal cells in lymphoid tissues, and immature B cells; B) Bcl-2 (+) is an antiapoptotic marker and is highly expressed in follicular lymphomas; C and D) CD3 (+) is a T-cell surface glycoprotein; E and F) CD20 (+) quantitatively identifies B lymphocytes.