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Journal of Epilepsy and Clinical Neurophysiology
On-line version ISSN 1980-5365
MENESES, Murilo S. et al. Epilepsy and malformations of cortical development disorders. J. epilepsy clin. neurophysiol. [online]. 2006, vol.12, n.3, pp.149-154. ISSN 1980-5365. http://dx.doi.org/10.1590/S1676-26492006000500007.
OBJECTIVES: Cortical development disorders (CDD) are the second cause of refratary epilepsy. Various patologies are included in the CDD. The diagnosis was easy with the continuous development of the neuroimaging. METHODS: In the present paper we show seven cases divided in three groups, accourding with the mecanism of production of the CDD: 1) proliferation and diferentiation abnormalities of the glial cells; 2) abnormalities of the neuronal migration; 3) abnormalities of the neuronal organization. The investigation consisted in story and neurological examination, neuropsicological avaliation, magnetic ressonance imaging and eletroencephalogram. RESULTS AND CONCLUSION: Three patients had focal cortical dysplasia; two had heterotopic band, one patient had lissecephaly and another had schizencephaly. All the patients had refractory epilepsy. Cortical malformations are a heterogeneous group of refractory epilepsy. Knowing and diagnosing these different types of cortical malformations are important steps for their treatment, and were facilitated by de advent of magnetic resonance imaging.
Keywords : epilepsy; cortical dysplasia; schizencephaly; lissencephaly; heterotopic band.