Journal of Epilepsy and Clinical Neurophysiology
versión On-line ISSN 1980-5365
GOMES, Maria Durce Costa; GARZON, Eliana y SAKAMOTO, Américo C.. The 50 years experience of adrenocorticotropic hormone (ACTH) use in West Syndrome: literatura review and UNIFESP protocol. J. epilepsy clin. neurophysiol. [online]. 2008, vol.14, n.1, pp. 27-32. ISSN 1980-5365. http://dx.doi.org/10.1590/S1676-26492008000100007.
INTRODUCTION: It is extensively discussed in the literature the efficacy of ACTH in West Syndrome (WS) as well, dosage, best protocols and side effects. OBJECTIVE: Analyze and discuss the most recent and relevant publication related to ACTH in patients with WS. METHODOLOGY: Literature publication was selected from MEDLINE and PUBMED between 1997 to 2007 using the following key words: "ACTH" and " West Syndrome". RESULTS: 96 titles were referral at medline and 158 at pubmed. 22 were selected and previous studies with special relevance were also included. CONCLUSIONS: There are evidences that ACTH probably has efficacy for immediately control of spasms and hypsarrhythmia. There is no evidence about the efficacy of ACTH in long term concerning seizures control and prevent delayed developmental).
Palabras clave : ACTH; West Syndrome; infantile spasms; hypsarrhythmia.