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Journal of Epilepsy and Clinical Neurophysiology

Print version ISSN 1676-2649

Abstract

QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. J. epilepsy clin. neurophysiol. [online]. 2009, vol.15, n.4, pp.165-168. ISSN 1676-2649.  http://dx.doi.org/10.1590/S1676-26492009000400005.

AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism.

Keywords : N-salicyloyltryptamine; anticonvulsant; PTZ; flumazenil; GABAA.

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