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vol.18 número1Níveis diferentes de MT-I/II entre pacientes com MTLE com ou sem crise generalizada: os níveis hipocampais de MT-I/II afetam o alastramento das crises, ou o alastramento das crises promove expressão diferencial de MT-I/II? índice de autoresíndice de assuntospesquisa de artigos
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Journal of Epilepsy and Clinical Neurophysiology

versão impressa ISSN 1676-2649

Resumo

ARAUJO FILHO, Gerardo Maria de et al. Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis. J. epilepsy clin. neurophysiol. [online]. 2012, vol.18, n.1, pp.21-25. ISSN 1676-2649.  https://doi.org/10.1590/S1676-26492012000100006.

OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression predicts an unfavorable outcome.

Palavras-chave : Temporal lobe epilepsy; mesial temporal sclerosis; epilepsy surgery; psychiatric disorders; seizure outcome.

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