SciELO - Scientific Electronic Library Online

 
vol.9 número3Estudos de medicamentos biosimilaresDissecção isolada do tronco celíaco: relato de caso índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Jornal Vascular Brasileiro

versão impressa ISSN 1677-5449

Resumo

PINTO, Valdair Ferreira. Non-inferiority clinical trials: concepts and issues. J. vasc. bras. [online]. 2010, vol.9, n.3, pp.145-151. ISSN 1677-5449.  http://dx.doi.org/10.1590/S1677-54492010000300009.

Non-inferiority trials are experimental models designed to determine whether a new treatment or procedure is not less effective than an established one, which is considered as standard. They are especially important in the assessment of treatments in which the use of placebo is impracticable. They differ substantially from the classical superiority trials and require different approach, especially in the planning and the data analysis. This paper is a review of the key differences between non-inferiority and traditional clinical studies. There is a considerable amount of misunderstanding on the correct use of this experimental design, which certainly compromises the credibility of some clinical assessments.

Palavras-chave : Clinical trial; Research Design; statistics & numerical data.

        · resumo em Português     · texto em Português | Inglês     · Português ( pdf epdf ) | Inglês ( pdf epdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons