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Jornal Vascular Brasileiro

versão impressa ISSN 1677-5449versão On-line ISSN 1677-7301

Resumo

ANDRADE, Luís Jesuíno de Oliveira; FRANCA, Larissa Santos; MELO, Paulo Roberto Santana de  e  ARAUJO, Marcelo. Off-label prescriptions in diabetic foot. J. vasc. bras. [online]. 2014, vol.13, n.3, pp.192-197. ISSN 1677-5449.  http://dx.doi.org/10.1590/jvb.2014.025.

Prescription of a drug outside of the indications for which it was originally approved by regulators is internationally known as "off-label" prescription. We describe off-label treatments for the diabetic foot reported in international scientific literature. This is a qualitative and descriptive bibliographical review based on the results of a search of the Medline international database. The criteria for review were publication between January 1985 and November 2013, and the MeSH (Medical Subject Heading) keywords "off-label use" OR "off-label" OR "off-label prescribing" plus "diabetic foot" were input on the search form. Nine studies were selected that contained information about off-label treatments for the diabetic foot. We conclude that the practice of off-label prescribing has potential benefits. In some situations an off-label prescription is the only treatment available for patients, either because a more targeted drug does not exist, or because other methods of treatment are ineffective or unavailable due to patient intolerance.

Palavras-chave : off-label use; diabetic foot; diabetes mellitus.

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