SciELO - Scientific Electronic Library Online

 
vol.18Comparison of the ankle-brachial index with parameters of stiffness and peripheral arterial resistance assessed by photoplethysmography in elderly patientsProphylactic catheterization of uterine arteries with temporary blood flow occlusion in patients at high risk of pospartum hemorrhage: is it a safe technique? author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Jornal Vascular Brasileiro

Print version ISSN 1677-5449On-line version ISSN 1677-7301

Abstract

PIATI, Polyana Klomfass et al. Analysis of recanalization of deep venous thrombosis: a comparative study of patients treated with warfarin vs. rivaroxaban. J. vasc. bras. [online]. 2019, vol.18, e20180111.  Epub June 27, 2019. ISSN 1677-5449.  http://dx.doi.org/10.1590/1677-5449.180111.

Background

Deep venous thrombosis (DVT) strikes around ten million people worldwide every year and is associated with major complications including pulmonary embolism and post-thrombotic syndrome. Anticoagulation is the standard treatment, with administration of heparins, vitamin K antagonists, fondaparinux, or, more recently, direct oral anticoagulants (DOACs). Anticoagulants reduce thrombus progression and facilitate natural thrombolytic mechanisms, leading to a phenomenon known as recanalization, which can occur in varying degrees and over variable periods of time, under influence from many different factors, including the type of anticoagulation employed.

Objectives

To evaluate the degree of recanalization and the time taken, by analysis of color Doppler ultrasonography (CDU) reports from patients with DVT treated with DOACs or with heparin + warfarin.

Methods

A retrospective analysis was conducted of demographic data and CDU reports from patients with DVT who had been treated from January 2009 to December 2016. These patients were classified into two groups, according to the treatment given: Group I (heparin + warfarin): 26 patients; or Group II (rivaroxaban): 51 patients. The primary outcomes assessed were degree of recanalization and time taken.

Results

Recanalization rates at 30, 90, and 180 days were 10%, 52.5%, and 78.9%, respectively, in Group I, and 55.3%, 83.5%, and 92.4%, respectively, in Group II, with statistically significant difference (p = 0.041).

Conclusions

Both treatments led to recanalization. Recanalization occurred earlier among patients treated with rivaroxaban.

Keywords : venous thrombosis; anticoagulant; ultrasonography doppler; Rivaroxaban; Warfarin.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf ) | Portuguese ( pdf )