SciELO - Scientific Electronic Library Online

vol.18 issue3Hand and ultrasonic instrumentation for orthograde root canal treatment of permanent teethSurvival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Journal of Applied Oral Science

Print version ISSN 1678-7757


CAMARGO, Samira Esteves Afonso et al. Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats. J. Appl. Oral Sci. [online]. 2010, vol.18, n.3, pp.273-278. ISSN 1678-7757.

Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL AND METHODS: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. RESULTS: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). CONCLUSIONS: These results demonstrate that the COB cement induces less inflammatory response within long periods.

Keywords : Calcium hydroxide; Castor oil; Pulp capping; Rats.

        · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License