SciELO - Scientific Electronic Library Online

vol.19 issue2Craniofacial characteristics of Caucasian and Afro-Caucasian Brazilian subjects with normal occlusionPeriodontal treatment during pregnancy decreases the rate of adverse pregnancy outcome: a controlled clinical trial author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Journal of Applied Oral Science

Print version ISSN 1678-7757


TUCCI, Renata et al. HOXB5 expression in oral squamous cell carcinoma. J. Appl. Oral Sci. [online]. 2011, vol.19, n.2, pp.125-129. ISSN 1678-7757.

Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL AND METHODS: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test. RESULTS: HOXB5 was amplifed in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. CONCLUSION: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.

Keywords : Genes, homeobox; Carcinoma, squamous cell; Gene expression; RT-PCR, neoplasm staging.

        · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License