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Journal of Venomous Animals and Toxins including Tropical Diseases

On-line version ISSN 1678-9199

Abstract

AYRES, J.A.; PERACOLI, M. T. S.  and  BARRAVIERA, B.. Evolution and prophylaxis of human rabies. J. Venom. Anim. Toxins incl. Trop. Dis [online]. 2005, vol.11, n.1, pp.8-21. ISSN 1678-9199.  http://dx.doi.org/10.1590/S1678-91992005000100003.

Rabies is a viral acute encephalitis of progressive and fatal outcome, particular of hot-blooded animals, and accidentally affecting men. Since it is a zoonosis with different animal species acting as a reservoir in the nature, this disease is a great public health problem in several countries in development. Prophylactic treatments for human rabies started in 1885 with Louis Pasteur, and developed in order to provide higher protection and lower incidence of side effects. Today, treatments of pre and post-exposure to the virus are well established, with excellent results of protection for individuals exposed to animals potentially contaminated by the rabies virus. These treatments consist of utilising the vaccine isolatedly or in combination with equine immunoglobulin, what contributes, in an important way, to the decrease in the number of cases of rabies.

Keywords : Human rabies; prophylaxis; heterologous serum; vaccine.

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