Contryphan-R |
GCOWEPWC
|
C. radiatus
|
“Stiff-tail” syndrome in mice |
[2020. Jimenéz EC, Olivera BM, Gray WR, Cruz LJ. Contryphan is a D-tryptophan-containing conus peptide. J Biol Chem. 1996;271(45):28002–5.] |
[des-Gly1]contryphan |
COWEPWC
|
C. radiatus
|
“Stiff-tail” syndrome in mice |
[2020. Jimenéz EC, Olivera BM, Gray WR, Cruz LJ. Contryphan is a D-tryptophan-containing conus peptide. J Biol Chem. 1996;271(45):28002–5.] |
Bromocontryphan-R |
GCOWEPW+C
|
C. radiatus
|
“Stiff-tail” syndrome in mice |
[2121. Jimenez EC, Craig AG, Watkins M, Hillyard DR, Gray WR, Gulyas J, et al. Bromocontryphan: post-translational bromination of tryptophan. Biochemistry. 1997;36(5):989–94.] |
Contryphan-Sm |
GCOWQPWC
|
C. stercusmuscarum
|
“Stiff-tail” syndrome in Webster mice |
[6969. Jacobsen R, Jimenez EC, Grilley M, Watkins M, Hillyard D, Cruz LJ, et al. The contryphans, a D-tryptophan-containing family of conus peptides: interconversion between conformers. J Pept Res. 1998;51(3):173–9.] |
Contryphan-P |
GCOWDPWC
|
C. purpurascens
|
“Stiff-tail” syndrome in Swiss Webster mice/inhibits HVA Ca2+ channels |
[6969. Jacobsen R, Jimenez EC, Grilley M, Watkins M, Hillyard D, Cruz LJ, et al. The contryphans, a D-tryptophan-containing family of conus peptides: interconversion between conformers. J Pept Res. 1998;51(3):173–9.] |
Leu-contryphan-P |
GCVLLPWC |
C. purpurascens
|
Body tremor and mucous secretion in fish |
[7070. Jacobsen RB, Jimenez EC, De la Cruz RG, Gray WR, Cruz LJ, Olivera BM. A novel D-leucine-containing conus peptide: diverse conformational dynamics in the contryphan family. J Pept Res. 1999;54(2):93–9.] |
Contryphan-Tx |
GCOWQPYC
|
C. textile
|
“Stiff-tail” syndrome and paralysis of extremities in Swiss Webster mice |
[7171. Jimenez EC, Watkins M, Juszczak LJ, Cruz LJ, Olivera BM. Contryphans from conus textile venom ducts. Toxicon. 2001;39(6):803–8.] |
Leu-contryphan-Tx |
CVLYPWC |
C. textile
|
Folding and drooping of dorsal fins and passivity in Siamese fighting fish |
[7171. Jimenez EC, Watkins M, Juszczak LJ, Cruz LJ, Olivera BM. Contryphans from conus textile venom ducts. Toxicon. 2001;39(6):803–8.] |
Contryphan-Vn |
GDCPWKPWC
|
C. ventricosus
|
? (VGPC, Ca2+ dependent) |
[2424. Massilia GR, Eliseo T, Grolleau F, Lapied B, Barbier J, Bournaud R, et al. Contryphan-Vn: a modulator of Ca2 + -dependent K+ channels. Biochem Biophys Res Commun. 2003;303(1):238–46., 7272. Massilia GR, Schinina ME, Ascenzi P, Polticelli F. Contryphan-Vn: a novel peptide from the venom of the Mediterranean snail conus ventricosus. Biochem Biophys Res Commun. 2001;288(4):908–13.] |
Glacontryphan-M |
NγSγCPWHPWC
|
C. marmoreus
|
Inhibits L-type VGCC |
[2222. Grant MA, Hansson K, Furie BC, Furie B, Stenflo J, Rigby AC. The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from conus marmoreus, glacontryphan-M. J Biol Chem. 2004;279(31):32464–73., 7373. Hansson K, Ma X, Eliasson L, Czerwiec E, Furie B, Furie BC, et al. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of conus marmoreus. J Biol Chem. 2004;279(31):32453–63.] |
Am975 |
GCPWDPWC
|
C. amadis
|
Inhibits HVA Ca2+ channels |
[2525. Sabareesh V, Gowd KH, Ramasamy P, Sudarslal S, Krishnan KS, Sikdar SK, et al. Characterization of contryphans from conus loroisii and conus amadis that target calcium channels. Peptides. 2006;27(11):2647–54.] |
Lo959 |
GCOWDPWC
|
C. loroisii
|
Activates HVA Ca2+ channels |
[2525. Sabareesh V, Gowd KH, Ramasamy P, Sudarslal S, Krishnan KS, Sikdar SK, et al. Characterization of contryphans from conus loroisii and conus amadis that target calcium channels. Peptides. 2006;27(11):2647–54.] |
Contryphan-fia |
GCODWQPWC |
C. figulinus
|
? |
[7474. Thakur SS, Balaram P. Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun Mass Spectrom. 2007;21(21):3420–6.] |
[W8S]contryphan-Vn |
GDCPWKPSC
|
C. ventricosus
|
? |
[7575. Nepravishta R, Mandaliti W, Melino S, Eliseo T, Paci M. Structure of the cyclic peptide [W8S] contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids. 2014;46(12):2841–53.] |
Contryphan-fib |
GCOWMPWC
|
C. figulinus
|
? |
[7676. Rajesh RP. Novel M-superfamily and T-superfamily conotoxins and contryphans from the vermivorous snail conus figulinus. J Pept Sci. 2015;21(1):29–39.] |