Brain |
|
Ventriculomegaly |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34., 2424. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R Jr. Zika: neurological and ocular findings in infant without microcephaly. Lancet. 2016;387(10037):2502., 3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16.] |
Cortical and subcortical calcifications |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34., 2424. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R Jr. Zika: neurological and ocular findings in infant without microcephaly. Lancet. 2016;387(10037):2502., 3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16., 3636. Štrafela P, Vizjak A, Mraz J, Mlakar J, Pižem J, Tul N, et al. Zika virus-associated micrencephaly: a thorough description of neuropathologic findings in the fetal central nervous system. Arch Pathol Lab Med. 2017;141(1):73–81., 3737. Soares de Souza A, Moraes Dias C, Braga FDCB, Terzian ACB, Estofolete CF, Oliani AH, et al. Fetal infection by Zika virus in the third trimester: report of 2 cases. Clin Infect Dis. 2016;63(12):1622–5., 3939. Mccarthy M. Zika congenital syndrome is seen in infants whose mothers had asymptomatic infection. BMJ. 2016;353:i3416., 4040. Alvarado MG, Schwartz DA. Zika virus infection in pregnancy, microcephaly, and maternal and fetal health: what we think, what we know, and what we think we know. Arch Pathol Lab Med. 2017;141(1):26–32., 5656. Paula FB de, Oliveira Dias JRJ de, Prazeres J, Sacramento GAG, Ko AI, Maia MM, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. J Am Med Assoc Ophthalmol. 2016; doi:10.1001/jamaophthalmol.2016.0267. https://doi.org/10.1001/jamaophthalmol.2...
] |
Agyria, taquigyria or polymicrogyria |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34., 3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16., 3535. Martines RB, Bhatnagar J, de Oliveira Ramos AM, Davi HPF, Iglezias SDA, Kanamura CT, et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet. 2016;388(10047):898–904.] |
Collapsed or dilated ventricle |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34., 5656. Paula FB de, Oliveira Dias JRJ de, Prazeres J, Sacramento GAG, Ko AI, Maia MM, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. J Am Med Assoc Ophthalmol. 2016; doi:10.1001/jamaophthalmol.2016.0267. https://doi.org/10.1001/jamaophthalmol.2...
] |
Agenesia |
[3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16.] |
Lysencephaly |
[2424. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R Jr. Zika: neurological and ocular findings in infant without microcephaly. Lancet. 2016;387(10037):2502., 3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16.] |
Hypoplasia of cerebellum |
[3535. Martines RB, Bhatnagar J, de Oliveira Ramos AM, Davi HPF, Iglezias SDA, Kanamura CT, et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet. 2016;388(10047):898–904.] |
Hydranencephaly |
[5555. Perez S, Tato R, Cabrera JJ, Lopez A, Robles O, Paz E, et al. Confirmed case of Zika virus congenital infection, Spain, march 2016. Euro Surveill. 2016;21(24) doi:10.2807/1560-7917.ES.2016.21.24.30261. https://doi.org/10.2807/1560-7917.ES.201...
, 5656. Paula FB de, Oliveira Dias JRJ de, Prazeres J, Sacramento GAG, Ko AI, Maia MM, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. J Am Med Assoc Ophthalmol. 2016; doi:10.1001/jamaophthalmol.2016.0267. https://doi.org/10.1001/jamaophthalmol.2...
] |
Loss of cerebral parenchyma volume |
[3434. Melo AS, Aguiar RS, Amorim MMR, Arruda MB, Melo FO, Ribeiro STC, et al. Congenital Zika virus infection: beyond neonatal microcephaly. J Am Med Assoc Neurol. 2016;73(12):1407–16.] |
Astroglyosis |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34.] |
Ocular |
|
Uveitis |
[2424. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R Jr. Zika: neurological and ocular findings in infant without microcephaly. Lancet. 2016;387(10037):2502.] |
Retinal degeneration |
[2424. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R Jr. Zika: neurological and ocular findings in infant without microcephaly. Lancet. 2016;387(10037):2502.] |
Neuroretinal atrophy |
[2828. Ventura CV, Maia M, Bravo-Filho V, Góis AL, Belfort R Jr. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016;387(10015):228.] |
Macular atrophy |
[6060. Kaur S, Jain S, Sodhi HBS, Rastogi A, Kamlesh. Optic nerve hypoplasia. Oman J Ophthalmol. 2013;6(2):77–82.] |
Optic nerve hypoplasia |
[5858. Dias JRO, Ventura CV, Borba PD, Freitas BP, Pierroti LC, Nascimento AP, et al. Infants with congenital Zika syndrome and ocular findings from São Paulo, Brazil: spread of infection. Retin Cases Brief Rep. 2017; doi:10.1097/ICB.0000000000000518. https://doi.org/10.1097/ICB.000000000000...
, 6060. Kaur S, Jain S, Sodhi HBS, Rastogi A, Kamlesh. Optic nerve hypoplasia. Oman J Ophthalmol. 2013;6(2):77–82.] |
Macular pigment mottling |
[2828. Ventura CV, Maia M, Bravo-Filho V, Góis AL, Belfort R Jr. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016;387(10015):228.] |
Chorioretinal scar |
[2828. Ventura CV, Maia M, Bravo-Filho V, Góis AL, Belfort R Jr. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016;387(10015):228., 5858. Dias JRO, Ventura CV, Borba PD, Freitas BP, Pierroti LC, Nascimento AP, et al. Infants with congenital Zika syndrome and ocular findings from São Paulo, Brazil: spread of infection. Retin Cases Brief Rep. 2017; doi:10.1097/ICB.0000000000000518. https://doi.org/10.1097/ICB.000000000000...
] |
Others |
|
Arthrogryposis |
[5454. Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, et al. Zika virus infection and stillbirths: a case of Hydrops Fetalis, Hydranencephaly and Fetal demise. PLoS Negl Trop Dis. 2016;10(2):e0004517., 5555. Perez S, Tato R, Cabrera JJ, Lopez A, Robles O, Paz E, et al. Confirmed case of Zika virus congenital infection, Spain, march 2016. Euro Surveill. 2016;21(24) doi:10.2807/1560-7917.ES.2016.21.24.30261. https://doi.org/10.2807/1560-7917.ES.201...
, 5656. Paula FB de, Oliveira Dias JRJ de, Prazeres J, Sacramento GAG, Ko AI, Maia MM, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital. J Am Med Assoc Ophthalmol. 2016; doi:10.1001/jamaophthalmol.2016.0267. https://doi.org/10.1001/jamaophthalmol.2...
] |
Intrauterine growth restriction |
[33. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375:2321–34.] |
Congenital contractures |
[3636. Štrafela P, Vizjak A, Mraz J, Mlakar J, Pižem J, Tul N, et al. Zika virus-associated micrencephaly: a thorough description of neuropathologic findings in the fetal central nervous system. Arch Pathol Lab Med. 2017;141(1):73–81.] |
Pulmonary hypoplasia |
[3636. Štrafela P, Vizjak A, Mraz J, Mlakar J, Pižem J, Tul N, et al. Zika virus-associated micrencephaly: a thorough description of neuropathologic findings in the fetal central nervous system. Arch Pathol Lab Med. 2017;141(1):73–81.] |
Craniofacial malformations |
[3636. Štrafela P, Vizjak A, Mraz J, Mlakar J, Pižem J, Tul N, et al. Zika virus-associated micrencephaly: a thorough description of neuropathologic findings in the fetal central nervous system. Arch Pathol Lab Med. 2017;141(1):73–81.] |