1 |
Alacaligenes faecalis
|
Aminoglycosides, chloramphenicol and tetracyclines |
Ponericin (G1, G3, W1, W3-desK, W4) |
Pachycondyla geoldii
|
[3333. Long SS, Pickering LK, Prober CG. Principles and practice of pediatric infectious disease: Elsevier Health Sciences; 2012., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9.] |
2 |
Acinetobacter baumannii.
|
Quinolone, beta-lactam/beta-lactamase inhibitor, cephalosporin and carbapenem |
Vejovine Crotalicidin Batroxicidin Mastoparan Lycosin II OH-CATH30 |
Vaejovis mexicanus,
Crotalus durissus terrificus,
Bothrops atrox,
Vespa basalis,
Vespa lewisii,
Lycosa singoriensis,
Ophiophagus hannah
|
[3535. Chen LK, Kuo SC, Chang KC, Cheng CC, Yu PY, Chang CH, et al. Clinical antibiotic-resistant Acinetobacter baumannii strains with higher susceptibility to environmental phages than antibiotic-sensitive strains. Sci Rep. 2017 Jul 24;7(1):6319.-4040. Zhao F, Lan XQ, Du Y, Chen PY, Zhao J, Zhao F, et al. King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates. Zool Res. 2018 Mar 18;39(2):87-96.] |
3 |
Bacillus cereus
|
Beta-lactam antibiotics such as ampicillin, oxacillin, penicillin, amoxicillin, and cefepime |
Ponericin (G4, G6, L2, W1, W3-desK, W4, W5, W6) Melectin Polybia (MP-II, MP-III) Defensin-NV Wa-PLA2 |
Pachycondyla geoldii,
Melecta albifrons,
Polybia paulista,
Nasonia vitripennis,
Walterinnesia aegyptia
|
[1212. Owusu-Kwarteng J, Wuni A, Akabanda F, Tano-Debrah K, Jespersen LJBm. Prevalence, virulence factor genes and antibiotic resistance of Bacillus cereus sensu lato isolated from dairy farms and traditional dairy products. BMC Microbiol. 2017 Mar 14;17(1):65., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 4141. Čeřovský V, Hovorka O, Cvačka J, Voburka Z, Bednárová L, Borovičková L, et al. Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. Chembiochem. 2008 Nov 24;9(17):2815-21.-4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6.] |
4 |
Bacillus subtilis
|
Chloramphenicol, tetracycline, rifampicin and streptomycin |
Ponericin (G1, G3, G4, G6, L2, W1, W3-desK, W4, W5, W6, Q42) Lasioglossin (LL-I, LL-II, LL-III) Lasiocepsin Halictine (1, 2) Macropin Panurgine I (PNG-I, K, R) Codesane Scorpine Heteroscorpine-I Bactridine (1, 2) 5Opistoporin 1 Pandinin (1, 2) Parabutoporin Mucroporin Imcroporin Ctriporin Lycocitin (I, II) Latarcin (1, 2a, 3a, 3b, 4a, 4b, 5, 6a, 7) Cyto-insectotoxin 1a Latartoxin 1a Mastoparan Mastoparan (B, PDD-A, PDD-B, MP, PMM) Agelaia-MP Protonectin Polybia-CP Anoplin Eumenitin Decoralin Crabrolin Dominulin (A, B) Wa-PLA2 |
Pachycondyla geoldii,
Ectatomma quadridens,
Lasioglossum laticeps, Lasioglossum laticeps, Halictus sexcinctus,
Macropis fulvipes,
Panurgus calcaratus,
Colletes daviesanus,
Pandinus imperator,
Heterometrus
laoticus,
Tityus discrepans,
Opistophtalmus carinatus,
Pandinus imperator,
Opistophtalmus carinatus,
Lychas
mucronatus,
Isometrus maculates,
Chaerilus tricostatus,
Lycosa singoriensis,
Lachesana tarabaevi,
Vespa basalis,
Vespa lewisii,
Polistes dorsalis dorsalis,
Mischocytarus phthisicus,
Polistes major major
Agelaia pallipes pallipes,
Polybia paulista,
Anoplius samarienis, Oreumenes
decorates,
Eumenes rubronotatus,
Vespa crabro,
Polistes dominulus,
Walterinnesia aegyptia
|
[2727. Monincová L, Veverka V, Slaninová J, Buděšínský M, Fučík V, Bednárová L, et al. Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae). J Pept Sci. 2014 Jun;20(6):375-84., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 4141. Čeřovský V, Hovorka O, Cvačka J, Voburka Z, Bednárová L, Borovičková L, et al. Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. Chembiochem. 2008 Nov 24;9(17):2815-21., 4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6.-7070. Krishnakumari V, Nagaraj R. Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs. J Pept Res. 1997 Aug;50(2):88-93.] |
5 |
Bacillus thuringiensis
|
Amoxicillin and ampicillin |
Lycotoxin (I, II) Anoplin Eumenitin Decoralin |
Lycosa carolinensis,
Anoplius samariensis,
Eumenes rubronotatus,
Oreumenes decorates
|
[6767. Konno K, Hisada M, Fontana R, Lorenzi CC, Naoki H, Itagaki Y, et al. Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis. Biochim Biophys Acta. 2001 Nov 26;1550(1):70-80.-6969. Konno K, Rangel M, Oliveira JS, dos Santos Cabrera MP, Fontana R, Hirata IY, et al. Decoralin, a novel linear cationic α-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. Peptides. 2007 Dec;28(12):2320-7., 7171. Bautista JR, Teves F. Antibiotic susceptibility testing of isolated Bacillus thuringiensis from three soil types around Iligan City, Philippines. African J Microbiol Res. 2013 Feb;7(8):678-82., 7272. Yan L, Adams ME. Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis. J Biol Chem. 1998;273(4):2059-66.] |
6 |
Citrobacter freundii
|
Penicillins, cephalosporins, ciprofloxacin, levofloxacin, aminoglycosides, phenicols, sulfonamides, tetracyclines and nitrofuran |
Pilosulin 1 Melittin |
Myrmecia pilosula,
Apis mellifera
|
[7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9.] |
7 |
Enterobacter cloacae
|
Beta-lactamases or carbapenemases ampicillin, amoxicillin-clavulanic acid, cephalothin, and cefoxitin |
Ponericin G1, G3, L2, W1, W3-desK, W4, W5 Hadrurin Vejovine Heterin (1, 2) Pantinin (1, 2, 3) Spiniferin Mastoparan (VT1, VT2, VT3, VT4, VT5, VT6) Anoplin Eumenitin |
Pachycondyla geoldii,
Hadrurus aztecus,
Vaejovis mexicanus,
Heterometrus spinifer,
Pandinus imperator,
Vespa basalis,
Vespula lewisii,
Anoplius samariensis, Eumenes rubronotatus
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 5656. Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. Eur J Biochem. 2000 Aug;267(16):5023-31., 6565. Mendes MA, de Souza BM, Marques MR, Palma MS. Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. Toxicon. 2004 Jul;44(1):67-74., 6767. Konno K, Hisada M, Fontana R, Lorenzi CC, Naoki H, Itagaki Y, et al. Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis. Biochim Biophys Acta. 2001 Nov 26;1550(1):70-80., 6868. Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, et al. Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus. Peptides. 2006 Nov;27(11):2624-31., 8181. Davin-Regli A, Pages JM. Enterobacter aerogenes and Enterobacter cloacae; versatile bacterial pathogens confronting antibiotic treatment. Front Microbiol. 2015 May 18;6:392.-8484. Yang X, Wang Y, Lee WH, Zhang Y. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica. Toxicon. 2013 Nov;74:151-7.] |
8 |
Escherchia coli
|
Ampicillin, amoxicillin, tetracycline, co-trimoxazole, streptomycin, ciprofloxacin, ofloxacin, cefotaxime, and gentamicin, chloramphenicol |
Ponericin (G1, G3, L2, W1, W3-desK, W4, W5, Q42, Q49, Q50) Pilosulin 1 Melittin Melectin Lasioglossin (LL-I, LL-II, LL-III) Lasiocepsin |
Pachycondyla geoldii,
Myrmecia pilosula,
Apis mellifera,
Melecta albifrons,
Lasioglosssum laticeps
|
[2222. Yang JL, Lu YA, Wu C, Tam JP. Antimicrobial and chemotactic activities of ω-conotoxin cyclic analogues. Peptides. 2001:487-8., 2323. Oguiura N, Boni-Mitake M, Affonso R, Zhang G. In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011 Mar 9;64(4):327-31., 2828. Páramo L, Lomonte B, Pizarro-Cerdá J, Bengoechea JA, Gorvel JP, Moreno E. Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--Synthetic Lys49 myotoxin II‐(115− 129)‐peptide identifies its bactericidal region. Eur J Biochem. 1998 Apr 15;253(2):452-61., 2929. Santamaría C, Larios S, Angulo Y, Pizarro-Cerda J, Gorvel JP, Moreno E, et al. Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region. Toxicon. 2005 Jun 1;45(7):807-15., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71., 3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 4141. Čeřovský V, Hovorka O, Cvačka J, Voburka Z, Bednárová L, Borovičková L, et al. Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. Chembiochem. 2008 Nov 24;9(17):2815-21.-4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6., 4646. Pluzhnikov KA, Kozlov SA, Vassilevski AA, Vorontsova OV, Feofanov AV, Grishin EV. Linear antimicrobial peptides from Ectatomma quadridens ant venom. Biochimie. 2014 Dec;107:211-5.-5252. Zhu S, Tytgat J. The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition. Cell Mol Life Sci. 2004 Jul;61(14):1751-63., 5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810.-5959. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, et al. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7., 6262. Lazarev VN, Polina NF, Shkarupeta MM, Kostrjukova ES, Vassilevski AA, Kozlov SA, et al. Spider venom peptides for gene therapy of Chlamydia infection. Antimicrob Agents Chemother. 2011 Nov;55(11):5367-9.-7070. Krishnakumari V, Nagaraj R. Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs. J Pept Res. 1997 Aug;50(2):88-93., 7272. Yan L, Adams ME. Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis. J Biol Chem. 1998;273(4):2059-66., 7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8282. Hernández-Aponte CA, Silva-Sanchez J, Quintero-Hernández V, Rodríguez-Romero A, Balderas C, Possani LD, et al. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus. Toxicon. 2011 Jan;57(1):84-92., 8383. Wu S, Nie Y, Zeng XC, Cao H, Zhang L, Zhou L, et al. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 Mar;53:30-41.-9696. Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, et al. Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018;13(1).] |
Halictine (1, 2) Macropin Panurgine I PNG-I, K, R) Codesane Scolopin (1, 2) Conolysin-Mt ω-conotoxin MVIIA Opiscorpine 1 Opistoporin 1 Parabutoporin Pandinin (1, 2) Hadrurin Vejovine Heterin (1, 2) Meucin (13, 18) Mucroporin Imcroporin Ctriporin Pantinin (1, 2, 3) Spiniferin Stigmurin Mauriporin Crotamin Crotalicidin Batroxicidin Lycotoxin (I, II) Lycocitin (I, II) Latarcin (2a, 3a, 3b, 4a, 4b, 5, 6a, 7) Cyto-insectotoxin 1a Latartoxin 1a Mastoparan Mastoparan (B, X, VT1, VT2, PDD-A, PDD-B, MP, PMM) Polybia-MP (I, II, III) Agelaia-MP Protonectin Polybia-CP Anoplin Eumenitin Decoralin Crabrolin Dominulin (A, B) Defensin-NV Myotoxin (II, III) Wa-PLA2 CTX-3 CTX-1 |
Halictus sexcintus,Macropis flavus,Panurgus calcaratus,Colletes daviesanus,Scolopendra subspinipes,Conus mustelinus,Conus spp., Opistophthalmus carinatus, Pandinus imperator, Hadrurus aztecus, Vaejivis mexicanus, Heterometrus spinifer, Mesobuthus eupeus, Lychas mucronatus, Isometrus maculates, Chaerilus tricostatus, Tityus stigmurus, Androctonus mauritanicus, Crotalus durissus, Crotalus durissus terrificus, Bothrops atrox, Lycosa carolinensis, Lycosa singoriensis, Lachesana tarabaevi, Vespa basalis, Vespa lewisii, Vespa spp., Polybia paulista, Agelaia pallipes pallipes, Anoplius samariensis, Oreumenes decorates, Eumenes rubronotatus, Vespa crabro, Polistes dominulus, Nasonia vitripennis, Bothrops asper, Walterinnesia aegyptia, Naja naja atra, Naja naja
|
9 |
Enterococcus faecalis
|
Tetracycline, erythromycin, ampicillin and ciprofloxacin |
Ponericin (G1, G3, L2, W1, W3-desK, W4, W5, W6) Melittin Bactridine (1, 2) Opistoporin 1 Hadrurin Pandinin (1, 2) Parabutoporin Crotalicidin Batroxicidin Mastoparan Mastoparan (B, VT1, VT2, VT3, VT6, VT7) Decoralin |
Pachycondyla geoldii,Apis mellifera,Tityus discrepans,Opistophtalmus carinatus,Hadrurus aztecus,Pandinus imperator,Opistophtalmus carinatus,Crotalus durissus terrificus,Bothrops atrox,Vespa basalis,Vespa spp., Oreumenes decorates
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71., 3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 5454. Díaz P, D’Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, et al. Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. Toxicon. 2009 Nov;54(6):802-17.-5757. Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, et al. Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochem J. 2001 Oct;359(Pt 1):35-45., 6969. Konno K, Rangel M, Oliveira JS, dos Santos Cabrera MP, Fontana R, Hirata IY, et al. Decoralin, a novel linear cationic α-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. Peptides. 2007 Dec;28(12):2320-7., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8484. Yang X, Wang Y, Lee WH, Zhang Y. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica. Toxicon. 2013 Nov;74:151-7., 9797. Golob M, Pate M, Kušar D, Dermota U, Avberšek J, Papić B, et al. Antimicrobial resistance and virulence genes in Enterococcus faecium and Enterococcus faecalis from humans and retail red meat. Biomed Res Int. 2019 May 9;2019.] |
10 |
Haemophilus influenza
|
Ampicillin, cefuroxime, clarithromycin, cefaclor, amoxicillin-clavulanate, and chloramphenicol |
Opistoporin 1 Parabutoporin |
Opistophtalmus carinatus
|
[5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810., 9898. Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, et al. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. Antimicrob Agents Chemother. 2010 Jan;54(1):65-71.] |
11 |
Klebsiella pneumonia
|
Trimethoprim/sulfamethoxazole, ceftriaxone, tobramycin, ciprofloxacin, piperacillin/tazobactam, ceftazidime, aztreonam. |
Ponericin (G1, G3, G4, G6, L2, W1, W3-desK, W4, W5) Pilosulin 1 Opistoporin 1 Hadrurin Parabutoporin Vejovine Mauriporin Crotalicidin Batroxicidin Mastoparan Mastoparan (B, VT1, VT2, VT3, VT4, VT6, VT7) Decoralin |
Pachycondyla geoldii,Myrmecia pilosula,Opistophtalmus carinatus,Hadrurus aztecus,Vaejivis mexicans,Androctonus mauritanicus,Crotalus durissus terrificus,Bothrops atrox,Vespa basalis,Vespa spp., Oreumenes decorates
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71.-3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6., 5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810., 5656. Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. Eur J Biochem. 2000 Aug;267(16):5023-31., 6969. Konno K, Rangel M, Oliveira JS, dos Santos Cabrera MP, Fontana R, Hirata IY, et al. Decoralin, a novel linear cationic α-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. Peptides. 2007 Dec;28(12):2320-7., 7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64., 8282. Hernández-Aponte CA, Silva-Sanchez J, Quintero-Hernández V, Rodríguez-Romero A, Balderas C, Possani LD, et al. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus. Toxicon. 2011 Jan;57(1):84-92., 8585. Almaaytah A, Tarazi S, Alsheyab F, Al-Balas Q, Mukattash T. Antimicrobial and antibiofilm activity of mauriporin, a multifunctional scorpion venom peptide. Int J Pept Res Ther. 2014 Apr 1;20(4):397-408., 9898. Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, et al. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. Antimicrob Agents Chemother. 2010 Jan;54(1):65-71., 9999. Sanchez GV, Master RN, Clark RB, Fyyaz M, Duvvuri P, Ekta G, et al. Klebsiella pneumoniae antimicrobial drug resistance, United States, 1998-2010. Emerg Infect Dis. 2013 Jan;19(1):133-6.] |
12 |
Pseudomonas aeruginosa
|
Fosfomycin, ciprofloxacin, levofloxacin, ceftazidime, piperacillin, imipenem, piperacillin, tobramycin, gentamicin, and meropenem |
Ponericin (G1, G3, G4, G6, L2, W1, W3-desK, W4, W5, W6, Q42) Pilosulin 1 Melittin Melectin Lasioglossin (LL-I, LL-II, LL-III) Halictine (1, 2) Lasiocepsin Macropin Panurgine I (PNG-I, K, R) Codesane Bactridine (1, 2) Opistoporin 1 Hadrurin Pandinin (1, 2) Parabutoporin Vejovine Mucroporin Imcroporin Ctriporin Mauriporin Crotamin Crotalicidin Batroxicidin Lycocitin II Latarcin (2a, 3a, 3b, 4a, 4b, 5, 6a, 7) Cyto-insectotoxin 1a Latartoxin 1a Mastoparan (VT1, VT2, VT3, VT4, VT6, VT7) Polybia-MP (I, II, III) Agelaia-MP Protonectin Polybia-CP Anoplin Eumenitin Defensin-NV Wa-PLA2 Lmut Tx CTX-1 |
Pachycondyla geoldii,Myrmecia pilosula,Apis mellifera,Melecta albifrons,Lasioglossum laticeps,Halictus sexcinctus,Macropis fulvipes,Panurgus calcarutus,Colletes daviesanus,Tityus discrepans,Opistophthalmus carinatus,Hadrurus aztecus,Pandinus imperator,Vaejivis mexicans,Lychas mucronatus,Isometrus maculates,Chaerilus tricostatus,Androctonus mauritanicus,Crotalus durissus,Crotalus durissus terrificus,Bothrops atrox,Lycosa singoriensis,Lachesana tarabaevi,Vespa spp., Polybia paulista, Agelaia pallipes pallipes, Polybia paulista, Anoplius samariensis, Eumenes rubronotatus, Nasonia vitripennis, Walterinnesia aegyptia, Lachesis muta muta, Naja naja
|
[2323. Oguiura N, Boni-Mitake M, Affonso R, Zhang G. In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011 Mar 9;64(4):327-31., 2727. Monincová L, Veverka V, Slaninová J, Buděšínský M, Fučík V, Bednárová L, et al. Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae). J Pept Sci. 2014 Jun;20(6):375-84., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 4141. Čeřovský V, Hovorka O, Cvačka J, Voburka Z, Bednárová L, Borovičková L, et al. Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. Chembiochem. 2008 Nov 24;9(17):2815-21.-4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6., 4646. Pluzhnikov KA, Kozlov SA, Vassilevski AA, Vorontsova OV, Feofanov AV, Grishin EV. Linear antimicrobial peptides from Ectatomma quadridens ant venom. Biochimie. 2014 Dec;107:211-5.-5151. Čujová S, Bednárová L, Slaninová J, Straka J, Čeřovský V. Interaction of a novel antimicrobial peptide isolated from the venom of solitary bee Colletes daviesanus with phospholipid vesicles and Escherichia coli cells. J Pept Sci. 2014 Nov;20(11):885-95., 5454. Díaz P, D’Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, et al. Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. Toxicon. 2009 Nov;54(6):802-17.-5959. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, et al. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7., 6161. Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV. Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. J Biol Chem. 2006 Jul 28;281(30):20983-92.-6868. Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, et al. Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus. Peptides. 2006 Nov;27(11):2624-31., 7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8282. Hernández-Aponte CA, Silva-Sanchez J, Quintero-Hernández V, Rodríguez-Romero A, Balderas C, Possani LD, et al. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus. Toxicon. 2011 Jan;57(1):84-92., 8484. Yang X, Wang Y, Lee WH, Zhang Y. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica. Toxicon. 2013 Nov;74:151-7., 9696. Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, et al. Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018;13(1)., 100100. Yayan J, Ghebremedhin B, Rasche K. Antibiotic resistance of Pseudomonas aeruginosa in pneumonia at a single university hospital center in Germany over a 10-year period. PLoS One. 2015 Oct 2;10(10):e0139836., 101101. Diniz-Sousa R, Caldeira CA, Kayano AM, Paloschi MV, Pimenta DC, Simões-Silva R, et al. Identification of the molecular determinants of the antibacterial activity of Lmut TX, a Lys49 phospholipase A2 homologue isolated from Lachesis muta muta snake venom (Linnaeus, 1766). Basic Clin Pharmacol Toxicol. 2018 Apr;122(4):413-23.] |
13 |
Pseudomonas flourescens
|
Meropenem, piperacillin/tazobactam and ceftazidime |
Melittin Heterin (1, 2) Spiniferin Cyto-insectotoxin 1a |
Apis mellifera,
Heterometrus spinifer,
Lachesana tarabaevi
|
[6363. Vassilevski AA, Kozlov SA, Samsonova OV, Egorova NS, Karpunin DV, Pluzhnikov KA, et al. Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem J. 2008 May;411(3):687-96., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8383. Wu S, Nie Y, Zeng XC, Cao H, Zhang L, Zhou L, et al. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 Mar;53:30-41., 102102. Kittinger C, Lipp M, Baumert R, Folli B, Koraimann G, Toplitsch D, et al. Antibiotic resistance patterns of Pseudomonas spp. isolated from the river Danube. Front Microbiol. 2016 May 3;7:586.] |
14 |
Proteus mirabilis
|
Fluoroquinolone, cephalosporin, gentamicin, trimethoprim-sulfamethoxazole, gentamicin |
Ponericin (G1, G3) Melittin Anoplin Eumenitin |
Pachycondyla geoldii,
Apis mellifera,
Anoplius samariensis,
Eumenes rubronotatus
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 6767. Konno K, Hisada M, Fontana R, Lorenzi CC, Naoki H, Itagaki Y, et al. Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis. Biochim Biophys Acta. 2001 Nov 26;1550(1):70-80., 6868. Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, et al. Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus. Peptides. 2006 Nov;27(11):2624-31., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 102102. Kittinger C, Lipp M, Baumert R, Folli B, Koraimann G, Toplitsch D, et al. Antibiotic resistance patterns of Pseudomonas spp. isolated from the river Danube. Front Microbiol. 2016 May 3;7:586.] |
15 |
Psuedomonas putida
|
Ciprofloxacin, norfloxacin, pefloxacin and ofloxacin, gentamycin, kanamycin, neomycin, streptomycin and netilmicin |
Ponericin (G1, G3, W1, W3-desK, W4) Heterin (1, 2) Pantinin (1, 2, 3) Spiniferin |
Pachycondyla geoldii,
Heterometrus spinifer,
Pandinus imperator,
Heterometrus spinifer
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 8383. Wu S, Nie Y, Zeng XC, Cao H, Zhang L, Zhou L, et al. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 Mar;53:30-41., 9292. Zeng XC, Zhou L, Shi W, Luo X, Zhang L, Nie Y, et al. Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 2013 Jul;45:28-34., 103103. Molina L, Udaondo Z, Duque E, Fernández M, Molina-Santiago C, Roca A, et al. Antibiotic resistance determinants in a Pseudomonas putida strain isolated from a hospital. PLoS One. 2014;9(1):e81604.] |
16 |
Staphylococcus aureus
|
Beta-lactams, glycopeptides, aminoglycosides, quinolones, oxazolinidones |
Ponericin (G1, G3, G6, W1, W3-desK, W4, W5, W6) Bicarinalin Pilosulin 1 Melittin Melectin Lasioglossin (LL-I, II, III) Halictine (1, 2) Lasiocepsin Macropin Panurgine I (PNG-I, K, R) Codesane Scolopin (1, 2) Conolysin-Mt ω-conotoxin MVIIA Opistoporin 1 Pandinin (1, 2) Parabutoporin Heterin (1, 2) Mucroporin Imcroporin Ctriporin Pantinin (1, 2, 3) Spiniferin Crotamin Crotalicidin Batroxicidin Cyto-insectotoxin 1a Mastoparan Mastoparan (B, VT1, VT2, VT3, VT4, VT6, VT7) Polybia-MP (I, II, III) Agelaia-MP Protonectin Polybia-CP Anoplin Eumenitin Decoralin Crabrolin Defensin-NV Myotoxin (II, III) Wa PLA2 PnPLA2 CTX-3 Lmut Tx OH-CATH30 CTX-1 |
Pachycondyla geoldii,Tetramorium bicarinatum,Myrmecia pilosula,Apis mellifera,Melecta albifrons,Lasioglossum laticeps,Halictus sexcinctus,Lasioglossum laticeps,Macropis fulvipes,Panurgus calcaratus,Colletes daviesanus,Scolopendra subspinipes mutilans,Conus mustelinus,Conus spp., Opistophthalmus carinatus, Pandinus imperator, Heterometrus spinifer, Lychas mucronatus, Isometrus maculates, Chaerilus tricostatus, Crotalus durissus, Crotalus durissus terrificus, Bothrops atrox, Lachesana tarabaevi, Vespa basalis, Vespa spp., Polybia paulista, Agelaia pallipes pallipes, Anoplius samariensis, Eumenes rubronotatus, Oreumenes decorates, Vespa crabro, Nasonia vitripennis, Bothrops asper, Walterinnesia aegyptia, Porthidium nasutum, Naja naja atra, Lachesis muta muta, Ophiophagus hannah, Naja naja,
|
[2222. Yang JL, Lu YA, Wu C, Tam JP. Antimicrobial and chemotactic activities of ω-conotoxin cyclic analogues. Peptides. 2001:487-8., 2323. Oguiura N, Boni-Mitake M, Affonso R, Zhang G. In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011 Mar 9;64(4):327-31., 2727. Monincová L, Veverka V, Slaninová J, Buděšínský M, Fučík V, Bednárová L, et al. Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae). J Pept Sci. 2014 Jun;20(6):375-84.-2929. Santamaría C, Larios S, Angulo Y, Pizarro-Cerda J, Gorvel JP, Moreno E, et al. Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region. Toxicon. 2005 Jun 1;45(7):807-15., 3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71.-3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 4040. Zhao F, Lan XQ, Du Y, Chen PY, Zhao J, Zhao F, et al. King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates. Zool Res. 2018 Mar 18;39(2):87-96.-4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6., 4747. Čeřovský V, Buděšínský M, Hovorka O, Cvačka J, Voburka Z, Slaninová J, et al. Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Chembiochem. 2009 Aug 17;10(12):2089-99.-5151. Čujová S, Bednárová L, Slaninová J, Straka J, Čeřovský V. Interaction of a novel antimicrobial peptide isolated from the venom of solitary bee Colletes daviesanus with phospholipid vesicles and Escherichia coli cells. J Pept Sci. 2014 Nov;20(11):885-95., 5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810., 5757. Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, et al. Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochem J. 2001 Oct;359(Pt 1):35-45.-5959. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, et al. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7., 6363. Vassilevski AA, Kozlov SA, Samsonova OV, Egorova NS, Karpunin DV, Pluzhnikov KA, et al. Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem J. 2008 May;411(3):687-96., 6565. Mendes MA, de Souza BM, Marques MR, Palma MS. Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. Toxicon. 2004 Jul;44(1):67-74.-7070. Krishnakumari V, Nagaraj R. Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs. J Pept Res. 1997 Aug;50(2):88-93., 7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8383. Wu S, Nie Y, Zeng XC, Cao H, Zhang L, Zhou L, et al. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 Mar;53:30-41., 8484. Yang X, Wang Y, Lee WH, Zhang Y. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica. Toxicon. 2013 Nov;74:151-7., 8787. Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, et al. Two novel antimicrobial peptides from centipede venoms. Toxicon. 2010 Feb-Mar;55(2-3):274-9., 8888. Biggs JS, Rosenfeld Y, Shai Y, Olivera BJB. Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry. 2007 Nov 6;46(44):12586-93., 9090. Santamaría C, Larios S, Quirós S, Pizarro-Cerda J, Gorvel JP, Lomonte B, et al. Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2. Antimicrob Agents Chemother. 2005 Apr;49(4):1340-5., 9292. Zeng XC, Zhou L, Shi W, Luo X, Zhang L, Nie Y, et al. Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 2013 Jul;45:28-34., 9595. Chen LW, Kao PH, Fu YS, Lin SR, Chang LS. Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity. Toxicon. 2011 Jul;58(1):46-53., 9696. Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, et al. Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018;13(1)., 104104. Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest. 2003 May 1;111(9):1265-73., 105105. Vargas LJ, Londoño M, Quintana JC, Rua C, Segura C, Lomonte B, et al. An acidic phospholipase A2 with antibacterial activity from Porthidium nasutum snake venom. Comp Biochem Physiol B Biochem Mol Biol. 2012 Apr;161(4):341-7.] |
17 |
Salmonella enterica
|
Fluoroquinolones, cephalosporins |
Ponericin (G1, G3, W1, W3-desK) Melittin Heterin (1, 2) Pantinin (1, 2, 3) Spiniferin Stigmurin Mauriporin Wa PLA2 |
Pachycondyla geoldii,
Apis mellifera,
Heterometrus spinifer,
Pandinus imperator,
Tityus stigmurus,
Androctonus mauritanicus , Walterinnesia aegyptia
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 4444. Bacha AB, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018 Oct 1;117:1140-6., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 8383. Wu S, Nie Y, Zeng XC, Cao H, Zhang L, Zhou L, et al. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 Mar;53:30-41., 8585. Almaaytah A, Tarazi S, Alsheyab F, Al-Balas Q, Mukattash T. Antimicrobial and antibiofilm activity of mauriporin, a multifunctional scorpion venom peptide. Int J Pept Res Ther. 2014 Apr 1;20(4):397-408., 9292. Zeng XC, Zhou L, Shi W, Luo X, Zhang L, Nie Y, et al. Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 2013 Jul;45:28-34., 9393. de Melo ET, Estrela AB, Santos ECG, Machado PRL, Farias KJS, Torres TM, et al. Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. Peptides. 2015 Jun;68:3-10., 106106. Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K, Saeed DK, et al. Emergence of an extensively drug-resistant Salmonella enterica serovar Typhi clone harboring a promiscuous plasmid encoding resistance to fluoroquinolones and third-generation cephalosporins. mBio. 2018 Feb 20;9(1):e00105-18.] |
18 |
Staphylococcus epidermidis
|
Methicillin, nafcillin, penicillin, cephalothin, cefamandole, streptomycin, and gentamicin |
Ponericin (G1, G3, G6, L2, W1, W3-desK, W4, W5, W6) Pilosulin 1 Pandinin(1, 2) Ctriporin Mauriporin Mastoparan Mastoparan B Polybia-CP Eumenitin Wa PLA2 |
Pachycondyla geoldii,
Myrmecia pilosula,
Pandinus imperator,
Chaerilus tricostatus,
Androctonus mauritanicus,
Vespa basalis,
Vespa lewisii,
Vespa basalis,
Polybia paulista,
Eumenes rubronotatus,
Walterinnesia aegyptia
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 5757. Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, et al. Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochem J. 2001 Oct;359(Pt 1):35-45., 5959. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, et al. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7., 6666. Wang K, Yan J, Chen R, Dang W, Zhang B, Zhang W, et al. Membrane-active action mode of polybia-CP, a novel antimicrobial peptide isolated from the venom of Polybia paulista. Antimicrob Agents Chemother. 2012 Jun;56(6):3318-23., 6868. Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, et al. Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus. Peptides. 2006 Nov;27(11):2624-31., 7373. Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A. Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64., 8585. Almaaytah A, Tarazi S, Alsheyab F, Al-Balas Q, Mukattash T. Antimicrobial and antibiofilm activity of mauriporin, a multifunctional scorpion venom peptide. Int J Pept Res Ther. 2014 Apr 1;20(4):397-408., 107107. Archer GL, Tenenbaum MJ. Antibiotic-resistant Staphylococcus epidermidis in patients undergoing cardiac surgery. Antimicrob Agents Chemother. 1980 Feb;17(2):269-72.] |
19 |
Shigella flexneri
|
Ampicillin, amoxicillin-clavulanic acid, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole, nalidixic acid and ciprofloxacin |
Mastoparan Mastoparan B |
Vespa basalis,Vespa spp. |
[3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 108108. Chu YW, Houang ET, Lyon DJ, Ling JM, Ng TKk, Cheng AF. Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995. Antimicrob Agents Chemother. 1998 Feb;42(2):440-3.] |
20 |
Serratia liquefaciens
|
Acylureidopenicillins, ticarcillin, cephalosporins, carbapenems, aztreonam, quinolones and antifolates |
Melittin |
Apis mellifera
|
[7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 109109. Stock I, Grueger T, Wiedemann B. Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesii. Int J Antimicrob Agents. 2003 Jul;22(1):35-47.] |
21 |
Serratia marcescens
|
Tetracycline, amoxycillin, amoxycillin/clavulanate and loracarbef |
Ponericin (G1, G3, G6, L2, W3-desK, W4, W5, W6) Melittin Opistoporin 1 Hadrurin Parabutoporin Cyto-insectotoxin 1a |
Pachycondyla geoldii,
Apis mellifera,
Opistophtalmus carinatus,
Hadrurus aztecus,
Lachesana tarabaevi
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810., 5656. Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. Eur J Biochem. 2000 Aug;267(16):5023-31., 6363. Vassilevski AA, Kozlov SA, Samsonova OV, Egorova NS, Karpunin DV, Pluzhnikov KA, et al. Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem J. 2008 May;411(3):687-96., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 109109. Stock I, Grueger T, Wiedemann B. Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesii. Int J Antimicrob Agents. 2003 Jul;22(1):35-47.] |
22 |
Streptococcus pnuemoniae
|
Beta-lactams, macrolides, lincosamides, fluoroquinolones, tetracyclines, and trimethoprim-sulfamethoxazole (TMP-SMX) |
Opistoporin 1 Parabutoporin Mastoparan - VT5 |
Opistophtalmus carinatus,
Vespa tropica
|
[5555. Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, et al. Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem. 2002 Oct;269(19):4799-810., 8484. Yang X, Wang Y, Lee WH, Zhang Y. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica. Toxicon. 2013 Nov;74:151-7., 110110. Cherazard R, Epstein M, Doan TL, Salim T, Bharti S, Smith MA. Antimicrobial resistant Streptococcus pneumoniae: prevalence, mechanisms, and clinical implications. Am J Ther. 2017 May;24(3):e361-e9.] |
23 |
Streptococcus pyogenes
|
Erythromycin, clarithromycin |
Ponericin (G1, G3, G4, G6, L2, W1, W3-desK, W4, W5, W6) Crotalicidin Batroxicidin Myotoxin (II, III) |
Pachycondyla geoldii,
Crotalus durissus terrificus,
Bothrops atrox,
Bothrops asper
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 3636. Falcao C, de La Torre B, Pérez-Peinado C, Barron A, Andreu D, Rádis-Baptista G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014 Nov;46(11):2561-71., 111111. Arvand M, Hoeck M, Hahn H, Wagner J. Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin. J Antimicrob Chemother. 2000 Oct;46(4):621-4.] |
24 |
Streprococcus sanguinis
|
Penicillin, amoxicillin, erythtromycin |
Ponericin (G1, G3, G4, G6, L2, W1, 3-desK, W4, W5, W6) Melittin |
Pachycondyla geoldii,
Apis mellifera
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 7575. Fennell JF, Shipman WH, Cole LJ. Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. Res Dev Tech Rep. 1967 Dec 5:1-13.-8080. Matanic VCA, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents. 2004 May;23(4):382-9., 112112. Erickson PR, Herzberg MC. Emergence of antibiotic resistant Streptococcus sanguis in dental plaque of children after frequent antibiotic therapy. Pediatr Dent. 1999 May-Jun;21:181-5.] |
25 |
Shigella sonnei
|
Ampicillin, amoxicillin-clavulanic acid, chloramphenicol, nalidixic acid, ciprofloxacin |
Mastoparan Mastoparan B Myotoxin (II, III) |
Vespa basalis,
Vespa basalis,
Bothrops asper
|
[3737. Park NG, Yamato Y, Lee S, Sugihara G. Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity. Biopolymers. 1995 Dec;36(6):793-801., 3838. Vila-Farres X, De La Maria CG, López-Rojas R, Pachón J, Giralt E, Vila J. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7., 108108. Chu YW, Houang ET, Lyon DJ, Ling JM, Ng TKk, Cheng AF. Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995. Antimicrob Agents Chemother. 1998 Feb;42(2):440-3.] |
26 |
Salmonella typhimurium
|
Streptomycin, sulfamethoxazole, tetracycline and ampicillin |
Mauriporin Crotamin Myotoxin (II, III) |
Androctonus mauritanicus,
Crotalus durissus,
Bothrops asper
|
[2323. Oguiura N, Boni-Mitake M, Affonso R, Zhang G. In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011 Mar 9;64(4):327-31., 2828. Páramo L, Lomonte B, Pizarro-Cerdá J, Bengoechea JA, Gorvel JP, Moreno E. Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--Synthetic Lys49 myotoxin II‐(115− 129)‐peptide identifies its bactericidal region. Eur J Biochem. 1998 Apr 15;253(2):452-61., 2929. Santamaría C, Larios S, Angulo Y, Pizarro-Cerda J, Gorvel JP, Moreno E, et al. Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region. Toxicon. 2005 Jun 1;45(7):807-15., 8585. Almaaytah A, Tarazi S, Alsheyab F, Al-Balas Q, Mukattash T. Antimicrobial and antibiofilm activity of mauriporin, a multifunctional scorpion venom peptide. Int J Pept Res Ther. 2014 Apr 1;20(4):397-408., 9090. Santamaría C, Larios S, Quirós S, Pizarro-Cerda J, Gorvel JP, Lomonte B, et al. Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2. Antimicrob Agents Chemother. 2005 Apr;49(4):1340-5., 113113. Tadesse DA, Singh A, Zhao S, Bartholomew M, Womack N, Ayers S, et al. Antimicrobial resistance in Salmonella in the United States from 1948 to 1995. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2567-71.] |
27 |
Yersinia
enterocolitica
|
Ampicillin, amoxicillin/clavulanic acid, and cefazolin |
Ponericin (G1, G2) Bactridine (1,2) |
Pachycondyla geoldii,
Tityus discrepans
|
[3434. Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, et al. Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9., 5454. Díaz P, D’Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, et al. Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. Toxicon. 2009 Nov;54(6):802-17., 8787. Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, et al. Two novel antimicrobial peptides from centipede venoms. Toxicon. 2010 Feb-Mar;55(2-3):274-9.] |
28 |
Mycobacterium tuberculosis
|
Rifampicin, isoniazid, floroquinolones, kanamycin, amikacin/capreomycin |
VpAmp 1.0 VpAmp 2.0 |
Vaejovis punctatus,
Vaejovis punctatus
|
[114114. Dookie N, Rambaran S, Padayatchi N, Mahomed S, Naidoo K. Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care. J Antimicrob Chemother. 2018 May 1;73(5):1138-51., 115115. Ramírez-Carreto S, Jiménez-Vargas JM, Rivas-Santiago B, Corzo G, Possani LD, Becerril B, et al. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity. Peptides. 2015 Nov;73:51-9.] |