Gussekloo et al.(
22 Gussekloo J, van Exel E, Craen AJ, Meinders AE, Frölich M, Western
RG. Thyroid status, disability and cognitive function and survival in old age.
JAMA. 2004;292(21):2591-9.
)
|
2004 |
Prospective cohort |
704 |
80-84 |
4.8 |
4 years |
Thyroid status, disability, cognition,
survival |
N/A |
Abnormally high levels of TSH may prolong life
span |
Surks et al.(
55 Surks MI, Hollowell JG. Age specific distribution of serum
thyrotropin and antithyroid antibodies in the US population: implications for
the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab.
2007;92(12):4575-82.
)
|
2007 |
SR of cohort |
16,533 |
12-80+ |
4.5 |
N/A |
Prevalence of SCH |
Report of thyroid disease, goiter, or use of
thyroid-related medications |
SCH is overestimated, unless an age-specific
range for TSH is used |
Rodondi et al.(
77 Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP,
Asvold BO, Iervasi G, Imaizumi M, Collet TH, Bremner A, Maisonneuve P, Sgarbi
JA, Khaw KT, Vanderpump MP, Newman AB, Cornuz J, Franklyn JA, Westendorp RG,
Vittinghoff E, Gussekloo J; Thyroid Studies Collaboration. Subclinical
hypothyroidism and the risk of coronary heart disease and mortality. JAMA.
2010;304(12):1365-74.
)
|
2010 |
SR of prospective cohort |
55,287 |
18-100 |
4.5 |
Variable |
CHD and CHD mortality |
Mainly symptomatic individuals and/or overt
hypothyroidism |
SCH associated with risk of CHD and CHD mortality
in individuals with TSH>10 mIU/L |
Hogervorst et al.(
99 Hogervorst E, Huppert F, Matthews FE, Brayne C. Thyroid function and
cognitive decline in the MRC Cognitive Function and Ageing Study.
Psychoneuroendocrinology. 2008;33(7):1013-22.
)
|
2008 |
Prospective cohort |
1,047 |
64-94 |
4.8 |
2 years |
Cognition |
Physical frailty or severe cognitive
impairment |
High log TSH levels associated with lower MMSE
scores |
Van den Beld et al.(
1111 Van den Beld A, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW.
Thyroid hormone concentrations, disease, physical function and mortality in
elderly men. J Clin Endocrinol Metab. 2005;90(12):6403-9.
)
|
2005 |
Cross-sectional |
403 |
73-94 |
4.3 |
4 years |
Thyroid hormones, physical function,
mortality |
Females, individuals who did not live
independently, severe mobility problems, severe systemic
disease, physical or mental incapacity to visit study
center |
Low serum fT4 associated with better 4-year
survival, reflecting an adaptive mechanism to prevent excessive
catabolism |
Atzmon et al.(
1414 Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I. Extreme
longevity is associated with increased serum thyrotropin. J Clin Endocrinol
Metab. 2009;94(4):1251-4.
)
|
2009 |
Case-control |
232 |
97+ |
4.0 |
NA |
Longevity and TSH |
NA |
TSH higher in centenarians and may contribute to
longevity |
Atzmon et al.(
1515 Aztmon G, Barzilai N, Surks MI, Gabriely I. Genetic predisposition
to elevated serum thyrotropin is associated with exceptional longevity. J Clin
Endocrinol Metab. 2009;94(12):4768-75.
)
|
2009 |
Case-control |
598 |
69-85+ |
4.0 |
NA |
Genetic of high TSH and longevity |
NA |
SNPs in the TSHR contribute to decreased thyroid
function and longevity |
Rozing et al.(
1616 Rozing MP, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, Frölich
M, de Craen AJ, et al. Familial longevity is associated with decreased thyroid
function. J Clin Endocrinol Metab. 2010;95(11):4979-84.
)
|
2010 |
Cross-sectional |
859 |
89+ |
4.8 |
N/A |
Longevity and thyroid function |
N/A |
Low thyroid activity constitutes a heritable
phenotype and contributes to familial longevity |
Corsonello et al.(
1717 Corsonello A, Montesanto A, Berardelli M, De Rango F, Dato S, Mari
V, et al. A cross-section analysis of FT3 age-related changes in a group of old
and oldest-old subjects, including centenarians’ relatives, shows that a
down-regulated thyroid function has a familial component and is related to
longevity. Age Ageing. 2010;39(6):723-7.
)
|
2010 |
Cross-sectional |
604 |
60-85+ |
4.2 |
N/A |
Longevity and thyroid function |
N/A |
Decreased thyroid function related to
longevity |
Spencer et al.(
1919 Spencer CA, Hollowell JG, Kazarosyan M, Braverman LE. National
Health and Nutrition Examination Survey III thyroid-stimulating hormone
(TSH)-thyroperoxidase antibody relationships demonstrate that TSH upper
reference limits may be skewed by occult thyroid dysfunction. J Clin Endocrinol
Metab. 2007;92(11):4236-40.
)
|
2008 |
SR of cohort |
16,088 |
12-80+ |
4.5 |
NA |
TSH and aTPO |
Report of thyroid disease or use of
thyroid-related medications |
Upper limits of TSH may be skewed by
aTPO-negative individuals with occult autoimmune thyroid
dysfunction |
Duarte et al.(
2020 Duarte GC, Tomimori EK, Camargo RY, Rubio IG, Wajngarten M,
Rodrigues AG, et al. The prevalence of thyroid dysfunction in elderly cardiology
patients with mild excessive iodine intake in the urban area of São Paulo.
Clinics. 2009;64 (2):135-42.
)
|
2009 |
Case-control |
399 |
60-92 |
4.0 |
NA |
Prevalence of thyroid dysfunction in the
elderly |
Report of thyroid or liver disease, thyroid
surgery, radioactive iodine therapy, radiologic tests with
contrast media or use of thyroid-related medications |
The elderly have higher prevalence of
hypothyroidism and thyroid nodules; one-third have elevated
urinary iodine excretion and autoimmune thyroiditis |
Benseñor et al.(
2121 Benseñor IM, Goulart AC, Lotufo PA, Menezes PR, Scazufca M.
Prevalence of thyroid disorders among older people: results from the São Paulo
Ageing & Health Study. Cad. Saúde Pública.
2011;27(1):155-61.
)
|
2011 |
Cross-sectional |
1,373 |
65-80+ |
5.0 |
N/A |
Prevalence of thyroid dysfunction in the
elderly |
N/A |
Prevalence of thyroid disease in men, and
undiagnosed hypothyroidism is higher |
Tonial et al.(
2222 Tonial R, Rosa LA, Rosa MI, Basso FO, Argente JS. Prevalência de
hipotireoidismo em residentes das seis instituições para idosos do município de
Criciúma – SC. Arq Catarinenses Med. 2007;36(4):37-41.
)
|
2007 |
Cross-sectional |
109 |
60-80 |
5.6 |
N/A |
Prevalence of hypothyroidism in the elderly |
N/A |
High prevalence of hypothyroidism |