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Einstein (São Paulo)

versão impressa ISSN 1679-4508versão On-line ISSN 2317-6385

Resumo

PRADO, Laura de Godoy Rousseff et al. Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features. Einstein (São Paulo) [online]. 2017, vol.15, n.1, pp.58-60. ISSN 1679-4508.  https://doi.org/10.1590/s1679-45082017ao3870.

Objective

To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis.

Methods

This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji’s criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms).

Results

We included 76 patients. The men/women ratio was 1.6:1. Participants’ mean age at disease onset was 55 years (SD±12.1). Sixty-six patients (86.8%) were able to complete psychiatric evaluation. Clinically significant anxiety was found in 23 patients (34.8%) while clinically significant depression was found in 24 patients (36.4%). When we compared patients with and without depression a significant difference was seen only in the frequency of anxiety symptoms (p<0.001). We did further analysis comparing subgroups of patients classified according to the presence or not of anxiety and or depression, without any significant difference regarding sex, age at onset, initial form, disease duration or functional measures. A positive correlation between anxiety and depressive symptoms was found (p<0.001).

Conclusion

Anxiety and depressive symptoms were highly correlated and frequent in patients with amyotrophic lateral sclerosis. In addition, anxiety and depression were not associated with disease duration and presentation, sex, age at onset, and functional score.

Palavras-chave : Amyotrophic lateral sclerosis/diagnosis; Depression; Anxiety.

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