Given the challenge of clinical diagnosis of bullous skin lesions, this report aimed to discuss the histological changes, the presentation and clinical reasoning for diagnosis of these lesions. At the same time, the importance of the pathology was reviewed to identify these clinical scenarios. In this case report, we highlighted the clinical progression of a case of pemphigus foliaceus.
Pemphigus; Skin diseases, vesiculobullous; Case reports
| Pemphigus diagnosis | Histology | Autoantigen |
|---|---|---|
| Pemphigus vulgaris | Intraepidermal suprabasal acantholysis | Dsg 3 |
| Tomb stone appearance | Dsg 1 | |
| Pemphigus foliaceus | Superficial subcorneal acantholysis | Dsg 1 |
| Dyskeratosis | ||
| Pemphigus herpetiformis | Subcorneal acantholysis | Dsg 1 |
| Dsg 3 | ||
| Dsc 1 | ||
| Dsc 3 | ||
| 178kDa protein | ||
| IgA pemphigus | Intraepidermal infiltration by neutrophilis or subcorneal infiltration by neutrophilis usually without classical acantholysis | Dsg 1 (IgA) |
| Dsg 3 (IgA) | ||
| Dsc (IgA) | ||
| Drug-induced pemphigus | Suprabasal acantholysis | Dsg 1 |
| Dsg 3 | ||
| Paraneoplastic pemphigus | Interface dermatitis, lichenoid infiltrate of the dermo-epidermal junction, keratinocyte necrosis | Envoplakin |
| Pariplakin (IgA, IgG) |
