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Einstein (São Paulo)

versão impressa ISSN 1679-4508versão On-line ISSN 2317-6385

Resumo

BACCI, Marcelo Rodrigues et al. Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients. Einstein (São Paulo) [online]. 2017, vol.15, n.4, pp.441-444. ISSN 1679-4508.  http://dx.doi.org/10.1590/s1679-45082017ao4012.

Objective:

To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m2.

Methods:

Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves.

Results:

Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point.

Conclusion:

These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level.

Palavras-chave : Beta-trace protein; Prostaglandins D/biosynthesis; Diabetes mellitus, type 2; Gene expression; Biomarkers/urine.

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