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Revista Dor

Print version ISSN 1806-0013


BERTOLINI, Gladson Ricardo Flor et al. Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats. Rev. dor [online]. 2014, vol.15, n.4, pp.287-289. ISSN 1806-0013.


Among electro agents ultrasound is one of the most common, however, there is insufficient evidence of the beneficial effects with the parameters currently used. The aim of this study was to compare the effect of continuous and pulsed ultrasound therapy on experimental hyperalgesia and edema in knees of Wistar rats.


18 rats were divided into three groups: CG- control group; GUP - treated with pulsed ultrasound 50%; and GUC - continuous ultrasound. To accomplish the lesion, animals were manually restrained and 100μL of 5% formalin solution were injected into the right tibiofemoral space. For assessment of nociception digital Von Frey filament was used on the medial side of the joint, until clinching. Edema was evaluated with mid-lateral knee caliper. Assessments occurred in the preinjury (EV1), after 15 (EV2), 30 (EV3) and 60 (EV4) minutes of the injury. After EV2, treatment was initiated with ultrasound with 0.4W/cm2 (SATA), pulsed or continuous.


The CG had hypernociception, with no return to baseline. GUP has returned to baseline as from EV3 and for continuous ultrasound in EV4. All three groups showed similar behavior for edema, with onset in EV2, without reduction.


Therapeutic ultrasound was effective to decrease nociception, and the pulsed form showed early results, however, both forms of application had no effect on the formation and maintenance of acute edema.

Keywords : Edema; Pain measurement; Ultrasound therapy.

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