SciELO - Scientific Electronic Library Online

 
vol.34 número6Acurácia do lavado gástrico realizado em ambiente hospitalar e ambulatorial no diagnóstico da tuberculose pulmonar em criançasEdema e hemorragia pulmonar por pressão negativa associados à obstrução das vias aéreas superiores índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Jornal Brasileiro de Pneumologia

versão impressa ISSN 1806-3713versão On-line ISSN 1806-3756

Resumo

DIAS-JUNIOR, Carlos Alan; CAU, Stefany Bruno de Assis  e  TANUS-SANTOS, José Eduardo. Role of nitric oxide in the control of the pulmonary circulation: physiological, pathophysiological, and therapeutic implications. J. bras. pneumol. [online]. 2008, vol.34, n.6, pp.412-419. ISSN 1806-3713.  http://dx.doi.org/10.1590/S1806-37132008000600012.

Nitric oxide (NO) is an endogenous vasoactive compound that contributes to pulmonary vascular homeostasis and is produced by three nitric oxide synthase (NOS) isoforms-neuronal NOS (nNOS); inducible NOS (iNOS); and endothelial NOS (eNOS)-all three of which are present in the lung. Studies using pharmacological inhibitors or knockout mice have shown that eNOS-derived NO plays an important role in modulating pulmonary vascular tone and attenuating pulmonary hypertension. However, studies focusing on the role of iNOS have shown that this isoform contributes to the pathophysiology of acute lung injury and acute respiratory distress syndrome. This review aimed at outlining the role played by NO in the control of pulmonary circulation, both under physiological and pathophysiological conditions. In addition, we review the evidence that the L-arginine-NO-cyclic guanosine monophosphate pathway is a major pharmacological target in the treatment of pulmonary vascular diseases.

Palavras-chave : Nitric oxide; Arginine; Nitric oxide synthase; Cyclic GMP; Pulmonary circulation.

        · resumo em Português     · texto em Português | Inglês     · Português ( pdf ) | Inglês ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons