Schein and Schilder (1975)1313. Schein B, Schilder H. Endotoxin content in endodontically involved teeth. J Endod. 1975 Jan;1(1):19-21. https://doi.org/10.1016/S0099-2399(75)80244-5 PMID:1061764 https://doi.org/10.1016/S0099-2399(75)80...
|
Vital pulp / healthy periodontium |
Gel clot |
0.007 µg/mL |
Irreversible pulpitis / healthy periodontium |
Gel clot |
0.075 µg/mL |
Schein and Schilder (1975)1313. Schein B, Schilder H. Endotoxin content in endodontically involved teeth. J Endod. 1975 Jan;1(1):19-21. https://doi.org/10.1016/S0099-2399(75)80244-5 PMID:1061764 https://doi.org/10.1016/S0099-2399(75)80...
|
Pulp necrosis / apical periodontitis |
Gel clot |
0.192 µg/mL |
Jacinto et al. (2005)1515. Jacinto RC, Gomes BP, Shah HN, Ferraz CC, Zaia AA, Souza-Filho FJ. Quantification of endotoxins in necrotic root canals from symptomatic and asymptomatic teeth. J Med Microbiol. 2005 Aug;54(Pt 8):777-83. https://doi.org/10.1099/jmm.0.45976-0
https://doi.org/10.1099/jmm.0.45976-0...
|
QCL |
18016.50 EU/mL |
Vianna et al. (2007)133133. Vianna ME, Horz HP, Conrads G, Zaia AA, Souza-Filho FJ, Gomes BP. Effect of root canal procedures on endotoxins and endodontic pathogens. Oral Microbiol Immunol. 2007 Dec;22(6):411-8. https://doi.org/10.1111/j.1399-302X.2007.00379.x
https://doi.org/10.1111/j.1399-302X.2007...
|
QCL |
151.61 EU/mL |
Martinho and Gomes (2008)1616. Martinho FC, Gomes BP. Quantification of endotoxins and cultivable bacteria in root canal infection before and after chemomechanical preparation with 2.5% sodium hypochlorite. J Endod. 2008 Mar;34(3):268-72. https://doi.org/10.1016/j.joen.2007.11.015
https://doi.org/10.1016/j.joen.2007.11.0...
|
QCL |
323.27 EU/mL |
Gomes et al. 2009(113113. Gomes BP, Martinho FC, Vianna ME. Comparison of 2.5% sodium hypochlorite and 2% chlorhexidine gel on oral bacterial lipopolysaccharide reduction from primarily infected root canals. J Endod. 2009 Oct;35(10):1350-3. https://doi.org/10.1016/j.joen.2009.06.011
https://doi.org/10.1016/j.joen.2009.06.0...
)
|
QCL |
212.23 EU/mL |
Martinho et al. (2010a)1111. Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP. Antigenic activity of bacterial endodontic contents from primary root canal infection with periapical lesions against macrophage in the release of interleukin-1beta and tumor necrosis factor alpha. J Endod. 2010a Sep;36(9):1467-74. https://doi.org/10.1016/j.joen.2010.06.012
https://doi.org/10.1016/j.joen.2010.06.0...
|
TKA |
9.19 EU/mL |
Martinho et al. (2010b),134134. Martinho FC, Chiesa WM, Marinho AC, Zaia AA, Ferraz CC, Almeida JF et al. Clinical investigation of the efficacy of chemomechanical preparation with rotary nickel-titanium files for removal of endotoxin from primarily infected root canals. J Endod. 2010b Nov;36(11):1766-9. https://doi.org/10.1016/j.joen.2010.08.019
https://doi.org/10.1016/j.joen.2010.08.0...
(2012),1717. Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP. Correlation between clinical/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content. J Endod. 2012 Jun;38(6):740-5. https://doi.org/10.1016/j.joen.2012.02.021
https://doi.org/10.1016/j.joen.2012.02.0...
(2014)2525. Martinho FC, Leite FR, Nascimento GG, Cirelli JA, Gomes BP. Clinical investigation of bacterial species and endotoxin in endodontic infection and evaluation of root canal content activity against macrophages by cytokine production. Clin Oral Investig. 2014 Dec;18(9):2095-102. https://doi.org/10.1007/s00784-014-1198-1
https://doi.org/10.1007/s00784-014-1198-...
|
TKA |
7490.00 pg/mL |
Martinho et al. (2011b)141141. Martinho FC, Chiesa WM, Zaia AA, Ferraz CC, Almeida JF, Souza-Filho FJ et al. Comparison of endotoxin levels in previous studies on primary endodontic infections. J Endod. 2011b Feb;37(2):163-7. https://doi.org/10.1016/j.joen.2010.11.020
https://doi.org/10.1016/j.joen.2010.11.0...
|
QCL |
34.20 EU/mL |
Martinho et al. (2011b)141141. Martinho FC, Chiesa WM, Zaia AA, Ferraz CC, Almeida JF, Souza-Filho FJ et al. Comparison of endotoxin levels in previous studies on primary endodontic infections. J Endod. 2011b Feb;37(2):163-7. https://doi.org/10.1016/j.joen.2010.11.020
https://doi.org/10.1016/j.joen.2010.11.0...
|
KQCL |
7.49 EU/mL |
Martinho et al. (2011b)141141. Martinho FC, Chiesa WM, Zaia AA, Ferraz CC, Almeida JF, Souza-Filho FJ et al. Comparison of endotoxin levels in previous studies on primary endodontic infections. J Endod. 2011b Feb;37(2):163-7. https://doi.org/10.1016/j.joen.2010.11.020
https://doi.org/10.1016/j.joen.2010.11.0...
|
TKA |
9.19 EU/mL |
Oliveira et al. (2011)135135. Oliveira LD, Carvalho CA, Carvalho AS, Alves JS, Valera MC, Jorge AO. Efficacy of endodontic treatment for endotoxin reduction in primarily infected root canals and evaluation of cytotoxic effects. J Endod. 2012 Aug;38(8):1053-7. https://doi.org/10.1016/j.joen.2012.04.015
https://doi.org/10.1016/j.joen.2012.04.0...
|
KQCL |
192.37 EU/mL |
Gomes et al. (2012)2020. Gomes BP, Endo MS, Martinho FC. Comparison of endotoxin levels found in primary and secondary endodontic infections. J Endod. 2012 Aug;38(8):1082-6. https://doi.org/10.1016/j.joen.2012.04.021
https://doi.org/10.1016/j.joen.2012.04.0...
|
TKA |
7.49 EU/mL |
Xavier et al. (2013)136136. Xavier AC, Martinho FC, Chung A, Oliveira LD, Jorge AO, Valera MC et al. One-visit versus two-visit root canal treatment: effectiveness in the removal of endotoxins and cultivable bacteria. J Endod. 2013 Aug;39(8):959-64. https://doi.org/10.1016/j.joen.2013.04.027
https://doi.org/10.1016/j.joen.2013.04.0...
|
KQCL |
153.13 EU/mL |
Marinho et al. (2014)137137. Marinho AC, Martinho FC, Zaia AA, Ferraz CC, Gomes BP. Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. J Appl Oral Sci. 2014 Nov-Dec;22(6):490-5. https://doi.org/10.1590/1678-775720130664
https://doi.org/10.1590/1678-77572013066...
|
TKA |
18.70 EU/mL |
Marinho et al. (2015)2929. Marinho AC, Martinho FC, Leite FR, Nascimento GG, Gomes BP. Proinflammatory activity of primarily infected endodontic content against macrophages after different phases of the root canal therapy. J Endod. 2015 Jun;41(6):817-23. https://doi.org/10.1016/j.joen.2015.01.017
https://doi.org/10.1016/j.joen.2015.01.0...
|
TKA |
32.43 EU/mL |
Herrera et al. (2015)3030. Herrera DR, Silva EJ, Santos CC, Zaia AA, Ferraz CC, Almeida JF, et al. Root canal content from primary endodontic infection and upregulation of gelatinases in fibroblast cells. Int Endod J. 2015 Dec;48(12):1168-74. https://doi.org/10.1111/iej.12421
https://doi.org/10.1111/iej.12421...
|
TKA |
21.83 EU/mL |
Cardoso et al. (2015)131131. Cardoso FG, Ferreira NS, Martinho FC, Nascimento GG, Manhães Junior LR, Rocco MA et al. Correlation between volume of apical periodontitis determined by cone-beam computed tomography analysis and endotoxin levels found in primary root canal infection. J Endod. 2015 Jul;41(7):1015-9. https://doi.org/10.1016/j.joen.2015.02.005
https://doi.org/10.1016/j.joen.2015.02.0...
|
KQCL |
10.92 EU/mL |
Herrera et al. (2017)139139. Herrera DR, Martinho FC, de-Jesus-Soares A, Zaia AA, Ferraz CC, Almeida JF et al. Clinical efficacy of EDTA ultrasonic activation in the reduction of endotoxins and cultivable bacteria. Int Endod J. 2017 Oct;50(10):933-40. https://doi.org/10.1111/iej.12713
https://doi.org/10.1111/iej.12713...
|
TKA |
27.72 EU/mL |
Endo et al. (2012),1919. Endo MS, Martinho FC, Zaia AA, Ferraz CC, Almeida JF, Gomes BP. Quantification of cultivable bacteria and endotoxin in post-treatment apical periodontitis before and after chemo-mechanical preparation. Eur J Clin Microbiol Infect Dis. 2012 Oct;31(10):2575-83. https://doi.org/10.1007/s10096-012-1598-6
https://doi.org/10.1007/s10096-012-1598-...
Gomes et al. (2012)2020. Gomes BP, Endo MS, Martinho FC. Comparison of endotoxin levels found in primary and secondary endodontic infections. J Endod. 2012 Aug;38(8):1082-6. https://doi.org/10.1016/j.joen.2012.04.021
https://doi.org/10.1016/j.joen.2012.04.0...
|
Previous root canal treatment / apical periodontitis |
TKA |
3.96 EU/mL |
Duque et al. (2018)140140. Duque TM, Prado M, Herrera DR, Gomes BP. Periodontal and endodontic infectious/inflammatory profile in primary periodontal lesions with secondary endodontic involvement after a calcium hydroxide-based intracanal medication. Clin Oral Investig. 2018 Mar. https://doi.org/10.1007/s00784-018-2401-6
https://doi.org/10.1007/s00784-018-2401-...
|
Vital pulp / chronic periodontal disease |
TKA |
0.10 EU/mL |