Sá et al. (2007)1616. Sá AR, Moreira PR, Xavier GM, Sampaio I, Kalapothakis E, Dutra WO et al. Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses. Int Endod J. 2007;40(7):563-72. https://doi.org/10.1111/j.1365-2591.2007.01272.x
https://doi.org/10.1111/j.1365-2591.2007...
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45 cases of symptomatic dental abscesses and 53 cases of asymptomatic inflammatory AP without previous exacerbation |
CD14 (-260 C/T, rs2569190)
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Genotype and allele distribution for the genetic polymorphism in IL6 was associated with symptomatic dental abscesses. |
IL1B (+3954 C/T, rs1143634)
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IL6 (-174 G/C, rs1800795)
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IL10 (-1082 G/A, rs1800896)
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TNFA (-308 G/A, rs1800629)
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Siqueira Junior et al. (2009)1717. Siqueira JF Jr, Rôças IN, Provenzano JC, Daibert FK, Silva MG, Lima KC. Relationship between Fcgamma receptor and interleukin-1 gene polymorphisms and post-treatment apical periodontitis. J Endod. 2009 Sep;35(9):1186-92. https://doi.org/10.1016/j.joen.2009.05.006
https://doi.org/10.1016/j.joen.2009.05.0...
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18 cases with PAP and 44 cases with root-canal-treated teeth exhibiting healthy/healing periradicular tissues |
FcgRIIA (R131 or H131, rs1801274)
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There was a statistical association observed for the genetic polymorphism in the FcγRIIIb gene (p<0.001). |
FCgRIIIB (NA1 or NA2, rs1050501)
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IL1A (–889, rs1800587)
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IL1B (+3954, rs1143634)
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Morsani et al. (2011)1818. Morsani JM, Aminoshariae A, Han YW, Montagnese TA, Mickel A. Genetic predisposition to persistent apical periodontitis. J Endod. 2011 Apr;37(4):455-9. https://doi.org/10.1016/j.joen.2011.01.009
https://doi.org/10.1016/j.joen.2011.01.0...
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34 cases with signs/symptoms of AP and 61 controls showing healing periradicular tissues |
IL1B (+3954, rs1143634)
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There was an association between the genetic polymorphisms and AP (p<0.001). |
Siqueira Junior et al. (2011)1919. Siqueira Junior JF, Rôças IN, Provenzano JC, Guilherme BP. Polymorphism of the FcγRIIIa gene and post-treatment apical periodontitis. J Endod. 2011 Oct;37(10):1345-8. https://doi.org/10.1016/j.joen.2011.06.025
https://doi.org/10.1016/j.joen.2011.06.0...
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26 cases with PAP and 43 cases with root-canal-treated teeth exhibiting healthy/healing periradicular tissues |
FcgRIIIA (V/F158, rs396991)
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The genetic polymorphism in FcγRIIIa was not associated with AP. |
Menezes-Silva et al. (2012)2020. Menezes-Silva R, Khaliq S, Deeley K, Letra A, Vieira AR. Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response. J Endod. 2012 May;38(5):604-7. https://doi.org/10.1016/j.joen.2012.02.009
https://doi.org/10.1016/j.joen.2012.02.0...
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158 cases with deep carious lesions but no periapical lesions, and 110 cases with periapical lesions and deep carious lesions |
MMP2 (rs243865, rs2285053, rs243847, rs2287074, rs9923304, rs11639960)
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The genetic polymorphisms rs639752 (p=0.03) and rs679620 (p=0.004) in MMP3 were associated with AP. An altered transmission of MMP2 haplotypes (p=0.000004) was observed. |
MMP3 (rs639752, rs650108, rs679620, rs522616)
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MMP9 (rs3918253, rs17576, rs17577)
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MMP13 (rs2252070)
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MMP14 (rs1042704)
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TIMP2 (rs9894526)
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Salazar-Pelaéz et al. (2012)2121. Salazar-Pelaéz LM, Fernández Grisales RO, Zulúaga Yepes OE, Vargas KO, Tobón Calle D. Il-1 gene polymorphisms and the risk of chronic periapical periodontitis in a population from Antioquia, Colombia. Arch Oral Biol. 2012;8(1):19-30.
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27 cases with PAP and 27 cases with a healthy periapex |
IL1A (-889, rs1800587)
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There was no association of the polymorphisms evaluated with AP (p>0.05). |
IL1B (+3954, rs1143634)
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Amaya et al. (2013)2222. Amaya MP, Criado L, Blanco B, Gómez M, Torres O, Flórez L et al. Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population. Int Endod J. 2013 Jan;46(1):71-8. https://doi.org/10.1111/j.1365-2591.2012.02097.x
https://doi.org/10.1111/j.1365-2591.2012...
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63 cases with acute suppurative AP and 57 diagnosed with chronic nonsuppurative AP |
IL1B (rs1143634)
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An association was observed for the genetic polymorphism IL8/CXCL8-251 (rs4073) (p=0.04). |
IL8/CXCL8 (rs4073)
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IL12B (rs3212227)
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TNFA (rs1800629)
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Rôças et al. (2014)2323. Rôças IN, Siqueira JF Jr, Del Aguila CA, Provenzano JC, Guilherme BP, Gonçalves LS. Polymorphism of the CD14 and TLR4 genes and post-treatment apical periodontitis. J Endod. 2014 Feb;40(2):168-72. https://doi.org/10.1016/j.joen.2013.10.006
https://doi.org/10.1016/j.joen.2013.10.0...
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41 cases with post-treatment PAP and 42 cases with root-canal-treated teeth exhibiting healthy/healing periradicular tissues |
CD14 (-260 C/T, rs2569190)
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There was no association of the polymorphisms evaluated with AP (p>0.05). |
TLR4 (+896A>G, rs4986790)
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Dill et al. (2015)2525. Dill A, Letra A, Souza LC, Yadlapati M, Biguetti CC, Garlet GP et al. Analysis of multiple cytokine polymorphisms in individuals with untreated deep carious lesions reveals IL1B (rs1143643) as a susceptibility factor for periapical lesion development. J Endod. 2015 Feb;41(2):197-200. https://doi.org/10.1016/j.joen.2014.10.016
https://doi.org/10.1016/j.joen.2014.10.0...
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136 cases with deep carious lesions and periapical lesions and 180 cases with deep carious lesions but no periapical lesions |
IL10 (rs5743626)
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Genetic polymorphism in IL1B (rs1143643) showed allelic (p=0.02) and genotypic (p=0.004) association with AP. |
IL1B (rs1143643, rs1143634 and rs16062)
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TNF (rs1800629)
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IL6 (rs2069830)
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OPG (rs1131380)
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RANKL (rs12721445)
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RANK (rs35589394)
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Evrosimovska et al. (2015)2424. Evrosimovska B, Dimova C, Popovska L, Zabokova-Bilbilova E. Matrix matalloproteinase-8 gene polymorphism in chronic periapical lesions. Prilozi. 2015;36(2):217-224. https://doi.org/10.1515/prilozi-2015-0070
https://doi.org/10.1515/prilozi-2015-007...
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120 cases with chronic AP and 120 cases without any signs of chronic or acute inflammatory process |
MMP8 (-799 C/T)
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MMP-8 polymorphism -799 C/T was a risk factor for expression of chronic AP (p<0.05). |
Maheshwari et al. (2016)2626. Maheshwari K, Silva RM, Guajardo-Morales L, Garlet GP, Vieira AR, Letra A. Heat Shock 70 Protein Genes and Genetic Susceptibility to Apical Periodontitis. J Endod. 2016 Oct;42(10):1467-71. https://doi.org/10.1016/j.joen.2016.07.010
https://doi.org/10.1016/j.joen.2016.07.0...
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183 cases with deep carious lesions and AP, and 217 cases with deep carious lesions but without AP |
HSPA4 (rs14355)
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Genetic polymorphisms in HSPA1L and HSPA6 showed significant allelic association (p<0.05). We also observed altered transmission of HSPA1L haplotypes (p=0.03). |
HSPA6 (rs1042881) |
HSPA1L (rs2075800, rs2227956 and rs2227955)
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HSPA4L (rs1380154)
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HSPA9 (rs1042665, rs10117) |
Trombone et al. (2016)2727. Trombone AP, Cavalla F, Silveira EM, Andreo CB, Francisconi CF, Fonseca AC et al. MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements. J Appl Oral Sci. 2016 Jul-Aug;24(4):366-75. https://doi.org/10.1590/1678-775720160112
https://doi.org/10.1590/1678-77572016011...
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111 patients presenting periapical granulomas, and 214 controls |
MMP1 (-1607 1G/2G, rs1799750)
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The MMP1-1607 1G/2G and 1G/2G+2G/2G genotypes were significantly more prevalent in AP patients than in the controls. |
Miri-Moghaddam et al. (2017)2828. Miri-Moghaddam E, Farhad-Mollashahi N, Baghaee E, Bazi A, Garme Y. Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess. J Clin Exp Dent. 2017 Feb;9(2):e196-201.
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50 cases with acute AP abscesses and 50 patients with asymptomatic AP |
TLR4 (Thr399Ile / 1196 C>T, rs4986791 and Asp299Gly / +896 A>G, rs4986790)
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The polymorphism Thr399Ile in TLR4 may play a role in the pathogenesis of acute apical abscesses. |
Petean et al. (2018)2929. Mazzi-Chaves JF, Petean IBF, Soares IMV, Salles AG, Antunes LAA, Segato RAB et al. Influence of genetic polymorphisms in genes of bone remodeling and angiogenesis process in the apical periodontitis. Braz Dent J. 2018 Mar-Apr;29(2):179-83. https://doi.org/10.1590/0103-6440201802260. https://doi.org/10.1590/0103-64402018022...
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64 cases with signs/symptoms of PAP and 84 subjects with root-canal-treated teeth exhibiting healthy periradicular tissues. |
RANK (rs3826620),
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Genetic polymorphisms in RANK rs3826620 (p=0.02) and RANKL rs9594738 (p=0.03) were associated with PAP. |
RANKL (rs9594738)
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OPG (rs2073618)
|