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Revista de Odontologia da UNESP

versão On-line ISSN 1807-2577


TINOS, Adriana Maria Fuzer Grael  e  SALES-PERES, Sílvia Helena de Carvalho. Xerostomia related to HIV infection /AIDS: a critical review. Rev. odontol. UNESP [online]. 2014, vol.43, n.3, pp.214-222. ISSN 1807-2577.


The presence of oral manifestations in HIV positive individuals is quite common. Xerostomia appears as one of the most frequent problems and may lead to a reduction in the quality of life of this population.


This study was a critical review of the relationship between xerostomia and HIV infection, to attract the attention of dentists on the importance of dental care to these patients.

Material and method:

We included articles published between 2000 and 2009, indexed in PUBMED database. The descriptors used were "HIV" and "xerostomia", the exclusion criteria adopted were: the absence of these descriptors associated, non-location of the full-text, articles based on case studies or case series and the absence of the abstract in the database.


Based on studies in the review, it can be said that the xerostomia is a common manifestation of HIV infection, predisposing the patient to several other oral problems. Among the risk factors for its occurrence it was reported: low counts of CD4+ T cells, high plasma viral load, the use of some medications and antiretroviral therapy.


The HIV/AIDS can change the salivary glands, and were considered important risk factors for the occurrence of xerostomia the presence of didanosine and the drug class which corresponds to protease inhibitors in antiretroviral therapy.

Palavras-chave : AIDS; HIV; saliva; antiretroviral therapy highly active; xerostomia.

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