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Revista de Odontologia da UNESP

versão impressa ISSN 0101-1774versão On-line ISSN 1807-2577

Resumo

SILVA JUNIOR, Aurélio Rosa da et al. Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats. Rev. odontol. UNESP [online]. 2018, vol.47, n.2, pp.119-123. ISSN 0101-1774.  http://dx.doi.org/10.1590/1807-2577.03718.

Introduction

With glutamine supplementation there is better performance in the body’s defense system.

Objective

The aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats.

Material and method

48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.

Result

In the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the EG group (116.63 ± 22.50 mm2 ) presented a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p<0.05. The GG (118.09 ± 10.4 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p>0.05.

Conclusion

Glutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.

Palavras-chave : Dietary supplements; periodontal diseases; products with antimicrobial action.

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