SciELO - Scientific Electronic Library Online

 
vol.65 issue12Repercussions of training and detraining by water-based exercise on functional fitness and quality of life: a short-term follow-up in healthy older womenMorphological and hemodynamic patterns of carotid stenosis treated by endarterectomy with patch closure versus stenting: a duplex ultrasound study author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Clinics

Print version ISSN 1807-5932

Abstract

SAVAS, Murat et al. Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction. Clinics [online]. 2010, vol.65, n.12, pp. 1311-1314. ISSN 1807-5932.  http://dx.doi.org/10.1590/S1807-59322010001200014.

OBJECTIVES: To investigate the acute effect of phosphodiesterase type 5 (PDE5) inhibitor on erectile dysfunction by evaluating serum oxidative status and prolidase activity. METHODS: Serum samples of 36 patients with erectile dysfunction and 30 control cases were analyzed for total antioxidant status, total oxidant status, and prolidase activity, before and after the administration of tadalafil citrate. RESULTS: Before and after tadalafil citrate administration, serum total antioxidant status, total oxidant status, and prolidase were 1.1+0.0 vs. 1.6 + 0.0 umol H2O2 Eq/L, 10.3+1.1 vs. 6.9 + 1.2 umol H2O2 Eq/L, and 236.4+19.5 vs. 228.2 + 19.2 U/L, respectively (p<0.0001 for all). CONCLUSIONS: Evaluation of serum oxidative status and prolidase activity confirmed the beneficial acute effects of PDE5 inhibitor in patients with erectile dysfunction.

Keywords : Phosphodiesterase type 5 inhibitors; Tadalafil citrate; Total antioxidant status; Total oxidant status; Prolidase.

        · text in English     · pdf in English