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Clinics

versão impressa ISSN 1807-5932

Resumo

LAZARINI, Mariana et al. PTK2 and PTPN11 expression in myelodysplastic syndromes. Clinics [online]. 2013, vol.68, n.10, pp.1371-1375. ISSN 1807-5932.  http://dx.doi.org/10.6061/clinics/2013(10)13.

OBJECTIVE:

The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes.

METHODS:

Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors.

RESULTS:

Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells.

CONCLUSIONS:

Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.

Palavras-chave : Myelodysplastic Syndromes; PTPN11; PTK2; FAK; SHP2.

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