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Clinics

Print version ISSN 1807-5932On-line version ISSN 1980-5322

Abstract

ZHOU, Qian et al. Clinical assessment of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for endometrial cancer. Clinics [online]. 2016, vol.71, n.1, pp.10-16. ISSN 1807-5932.  http://dx.doi.org/10.6061/clinics/2016(01)03.

OBJECTIVE:

The aim of this study was to determine the efficacy of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for the treatment of endometrial cancer.

METHODS:

Thirty-one patients with stage I-III endometrial cancer were recruited for this study. The stage I patients received only 252Californium neutron intracavitary brachytherapy with a two-channel applicator. The stage II and III patients received both 252Californium neutron intracavitary brachytherapy using a two-channel applicator and parallel-opposed whole pelvic radiotherapy.

RESULTS:

The five-year local control rate was 80.6% (25/31), the overall survival rate was 51.6% (16/31), and the disease-free survival rate was 54.8% (17/31). The incidence of serious late complications was 12.9% (4/31).

CONCLUSIONS:

252Californium neutron intracavitary brachytherapy using a two-channel applicator combined with external beam radiotherapy was effective for treating endometrial cancer and the incidence of serious late complications related to this combination was within an acceptable range.

Keywords : Endometrial Cancer; Californium; Two-Channel Y Applicator.

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