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Clinics

versão impressa ISSN 1807-5932versão On-line ISSN 1980-5322

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TAVARES, Cléciton Braga et al. Expression of estrogen and progesterone receptors in astrocytomas: a literature review. Clinics [online]. 2016, vol.71, n.8, pp.481-486. ISSN 1807-5932.  https://doi.org/10.6061/clinics/2016(08)12.

Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones. A literature review for the presence of estrogen and progesterone receptors in astrocytomas was conducted in the PubMed database using the following MeSH terms: “estrogen receptor beta” OR “estrogen receptor alpha” OR “estrogen receptor antagonists” OR “progesterone receptors” OR “astrocytoma” OR “glioma” OR “glioblastoma”. Among the 111 articles identified, 13 studies met our inclusion criteria. The majority of reports showed the presence of estrogen and progesterone receptors in astrocytomas. Overall, higher tumor grades were associated with decreased estrogen receptor expression and increased progesterone receptor expression.

Palavras-chave : Estrogen Receptor Alpha; Estrogen Receptor Beta; Progesterone Receptor; Astrocytoma.

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