Batistatou, A et al. |
2004 |
J Cancer Clin Oncol |
Greece |
ERβ is mainly expressed in normal astrocytes and in astrocytes of low-grade gliomas. Its presence decreases with increased malignancy of these tumors. |
Batistatou A et al. |
2006 |
Journal of Neuro-Oncology |
Greece |
ERβ expression is found in gliomas and oligodendrogliomas and ERβ expression tends to decrease with increased histological malignancy of the tumor. Regression models and Kaplan-Meier curves showed better prognosis and longer survival times for patients with ERβ-positive tumors. |
Cabrera-Munoz E |
2009 |
Journal of Steroid Biochemistry & Molecular Biology |
Mexico |
The regulation of PR expression depends on the histological grade of the astrocytoma. PR-A inhibits the effects of progesterone on growing astrocytoma cells. |
Cabrera-Muãoz E et al. |
2011 |
Current Topics in Medicinal Chemistry |
Mexico |
PR expression is correlated with the histological malignancy of gliomas, and PR-B is the predominant isoform in high-grade gliomas. |
Sareddy G.R et al. |
2012 |
Molecular Cancer Therapeutics |
USA |
ERβ expression is found in normal brain tissue and in low-grade gliomas. ERβ expression decreases with the progression of glial tumors. In high-grade gliomas, these receptors are found mainly in the cytoplasm of tumor cells. ERβ agonists inhibit the growth of gliomas in cells in vivo. |
Hernández-Hernández O.T et al. |
2012 |
Journal of Steroid Biochemistry & Molecular Biology |
Mexico |
Progesterone regulates VEGF and EGFR expression differently in astrocytoma cells by interactions with PR and SRC-1. |
González-Arenas A et al. |
2012 |
Biochimica et Biophysica Acta |
Mexico |
Estrogen induces the growth of human astrocytomas by interaction with ERα and recruitment of SRC-1 and SRC-3, regulating the expression of genes responsible for cell proliferation and angiogenesis. |
Wenjun Lia et al. |
2013 |
Brain Research |
USA |
ERβ5 is the main ERβ isoform found in gliomas. Its expression is higher in neoplasms than in normal brain tissue and increases with higher grades of cell dedifferentiation. |
Jimenez J.M.D et al. |
2014 |
Journal of Neuro-Oncology |
Mexico |
There is a negative correlation between ERα expression and the malignancy grade of gliomas.There is a positive correlation between ERα expression and the survival time of patients suffering from gliomas. |
Liu C et al. |
2014 |
Cancer Epidemiology |
China |
ERs are present in normal brain tissues and in gliomas. There is a significant reduction in ERα and ERβ expression with increased histological malignancy of the tumor. |
Germán-Castelán L et al. |
2014 |
Biomed Research International |
2014 |
Progesterone induces the proliferation and infiltration of human anaplastic astrocytomas cells implanted in the rat motor cortex by interaction with PR. |
Atif F et al. |
2015 |
Journal of Steroid Biochemistry & Molecular Biology |
USA |
High doses of progesterone inhibit the in vitro growth of human glioblastoma multiforme, mainly by inhibiting cell growth and tumor angiogenesis and inducing apoptosis regardless of the interaction with PR. |
González-Arenas A et al. |
2015 |
General Endocrinology |
Mexico |
Protein C kinase α (PKCα) phosphorylates PR, and these receptors increase the genetic transcription and multiplication of astrocytomas. |