Oh E, et al. 2014 (2828. Oh E, Stull ND, Mirmira RG, Thurmond DC. Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab. 2014;99(5):E866–70, http://dx.doi.org/10.1210/jc.2013-2221. http://dx.doi.org/10.1210/jc.2013-2221...
)
|
NOD-SCID mice |
N/A |
10-14 weeks |
Streptozotocin 180 mg/kg |
X |
|
Wu DC, et al. 2013 (1414. Wu DC, Hester J, Nadig SN, Zhang W, Trzonkowski P, Gray D, et al. Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model. Transplantation. 2013;96(8):707–16, http://dx.doi.org/10.1097/TP.0b013e31829fa271. http://dx.doi.org/10.1097/TP.0b013e31829...
15. Sá JR, Gonzalez AM, Melaragno CS, Saitovich D, Franco DR, Rangel EB, et al. [Pancreas and islet transplantation in patients with diabetes mellitus]. Arq Bras Endocrinol Metabol. 2008;52(2):355–66, http://dx.doi.org/10.1590/S0004-27302008000200024. http://dx.doi.org/10.1590/S0004-27302008...
)
|
BALB/c mice |
N/A |
6-12 weeks |
Streptozotocin 250 mg/kg |
X |
|
Brandhorst D, et al. 2013 (2929. Brandhorst D, Brandhorst H, Maataoui V, Maataoui A, Johnson PR. Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets. Apoptosis. 2013;18(6):681–8, http://dx.doi.org/10.1007/s10495-013-0834-6. http://dx.doi.org/10.1007/s10495-013-083...
)
|
C57BL/6 mice |
N/A |
N/A |
N/A |
|
X |
Liu S, et al. 2013 (3030. Liu S, Kilic G, Meyers MS, Navarro G, Wang Y, Oberholzer J, et al. Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia. 2013;56(2):370–81, http://dx.doi.org/10.1007/s00125-012-2764-1. http://dx.doi.org/10.1007/s00125-012-276...
)
|
C57BL/6 mice |
Male |
10 weeks |
Streptozotocin 200 mg/kg |
X |
|
Qi M, et al. 2012 (2727. Qi M, Mørch Y, Lacík I, Formo K, Marchese E, Wang Y, et al. Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+. Xenotransplantation. 2012;19(6):355–64, http://dx.doi.org/10.1111/xen.12009. http://dx.doi.org/10.1111/xen.12009...
)
|
BALB/c mice |
N/A |
N/A |
N/A |
|
X |
Avgoustiniatos ES, et al. 2012 (3131. Avgoustiniatos ES, Scott WE 3rd, Suszynski TM, Schuurman HJ, Nelson RA, Rozak PR, et al. Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum. Cell Transplant. 2012;21(12):2805–14, http://dx.doi.org/10.3727/096368912X653138. http://dx.doi.org/10.3727/096368912X6531...
)
|
N/A |
N/A |
N/A |
Streptozotocin (dose: N/A) |
|
X |
Noguchi H, et al. 2012 (44. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, et al. Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant. 2012;21(2-3):517–23, http://dx.doi.org/10.3727/096368911X605439. http://dx.doi.org/10.3727/096368911X6054...
)
|
N/A |
N/A |
N/A |
Streptozotocin 220 mg/kg |
|
X |
Pour PM, et al. 2012 (3232. Pour PM. A novel tissue for islet transplantation in diabetics. Pancreatology. 2012;12(1):57–60, http://dx.doi.org/10.1016/j.pan.2011.11.002. http://dx.doi.org/10.1016/j.pan.2011.11....
)
|
Syrian Golden hamsters |
Female |
8 years |
Streptozotocin 50 mg/kg |
X |
|
McCall M, et al. 2011 (3333. McCall M, Toso C, Emamaullee J, Pawlick R, Edgar R, Davis J, et al. The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice. Surgery. 2011;150(1):48–55, http://dx.doi.org/10.1016/j.surg.2011.02.023. http://dx.doi.org/10.1016/j.surg.2011.02...
)
|
C57BL/6 mice |
N/A |
N/A |
Streptozotocin (220mg/kg - BALB/c; 180mg/kg - B6-RAG-/-) |
|
X |
Mwangi SM, et al. 2011 (3434. Mwangi SM, Usta Y, Shahnavaz N, Joseph I, Avila J, Cano J, et al. Glial cell line-derived neurotrophic factor enhances human islet posttransplantation survival. Transplantation. 2011;92(7):745–51, http://dx.doi.org/10.1097/TP.0b013e31822bc95a. http://dx.doi.org/10.1097/TP.0b013e31822...
)
|
athymic nude Foxn1-nu mice |
N/A |
6 weeks |
Streptozotocin 75 mg/kg |
X |
|
Zhang J, et al. 2010 (2020. Zhang J, Li H, Jiang N, Wang GY, Fu BS, Wang GS, et al. Inhibition of rejection in murine islet xenografts by CTLA4Ig and CD40LIg gene transfer. Chin Med J (Engl). 2010;123(21):3106–9.)
|
NOD/LtJ mice |
Female |
N/A |
N/A |
|
X |
Sabek O, et al. 2010 (3535. Sabek O, Gaber MW, Wilson CM, Zawaski JA, Fraga DW, Gaber O. Imaging of human islet vascularization using a dorsal window model. Transplant Proc. 2010;42(6):2112–4, http://dx.doi.org/10.1016/j.transproceed.2010.05.080. http://dx.doi.org/10.1016/j.transproceed...
)
|
N/A |
Female |
10-12 weeks |
N/A |
|
X |
Rink JS, et al. 2010 (3636. Rink JS, McMahon KM, Chen X, Mirkin CA, Thaxton CS, Kaufman DB. Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles. Surgery. 2010;148(2):335–45, http://dx.doi.org/10.1016/j.surg.2010.05.013. http://dx.doi.org/10.1016/j.surg.2010.05...
)
|
N/A |
N/A |
N/A |
Streptozotocin 220 mg/kg |
|
x |
Brehm MA, et al. 2010 (1919. Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, et al. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes. 2010;59(9):2265–70, http://dx.doi.org/10.2337/db10-0323. http://dx.doi.org/10.2337/db10-0323...
)
|
NOD SCID gamma mice |
N/A |
12-16 weeks |
Spontaneous: 3-5 week-old |
x |
|
Sklavos MM, et al. 2010 (2121. Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, et al. Redox modulation protects islets from transplant-related injury. Diabetes. 2010;59(7):1731–8, http://dx.doi.org/10.2337/db09-0588. http://dx.doi.org/10.2337/db09-0588...
)
|
C57BL/6 and BALB/c |
Male |
6-8 weeks |
Streptozotocin 240 mg/kg |
x |
|
Jacobs-Tulleneers-Thevissen D, et al. 2010 (3737. Jacobs-Tulleneers-Thevissen D, Bartholomeus K, Suenens K, Vermeulen I, Ling Z, Hellemans KH, et al. Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity. Diabetologia. 2010;53(8):1690–9, http://dx.doi.org/10.1007/s00125-010-1721-0. http://dx.doi.org/10.1007/s00125-010-172...
)
|
Rowett rats |
Male |
7-10 weeks |
Streptozotocin 60 mg/kg |
x |
|
Yamamoto T, et al. 2010 (2222. Yamamoto T, Mita A, Ricordi C, Messinger S, Miki A, Sakuma Y, et al. Prolactin supplementation to culture medium improves beta-cell survival. Transplantation. 2010;89(11):1328–35, http://dx.doi.org/10.1097/TP.0b013e3181d98af1. http://dx.doi.org/10.1097/TP.0b013e3181d...
)
|
N/A |
N/A |
N/A |
Streptozotocin 200 mg/kg |
|
x |
Toso C, et al. 2010 (3838. Toso C, McCall M, Emamaullee J, Merani S, Davis J, Edgar R, et al. Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture. Transpl Int. 2010;23(3):259–65, http://dx.doi.org/10.1111/j.1432-2277.2009.00984.x. http://dx.doi.org/10.1111/j.1432-2277.20...
)
|
C57BL/6 mice |
Female and Male |
N/A |
Streptozotocin 175 mg/kg |
x |
|
Höglund E, et al. 2009 (3939. Höglund E, Mattsson G, Tyrberg B, Andersson A, Carlsson C. Growth hormone increases beta-cell proliferation in transplanted human and fetal rat islets. JOP. 2009;10(3):242–8.)
|
C57BL/6 mice |
Male |
N/A |
N/A |
|
x |
Lee SH, et al. 2009 (4040. Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P. Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies. Transplantation. 2009;87(7):983–91, http://dx.doi.org/10.1097/TP.0b013e31819c86ea. http://dx.doi.org/10.1097/TP.0b013e31819...
)
|
SCID-Beige mice |
N/A |
8 weeks |
Streptozotocin 40 mg/kg |
x |
|
Scharfmann R, et al. 2008 (2323. Scharfmann R, Xiao X, Heimberg H, Mallet J, Ravassard P. Beta cells within single human islets originate from multiple progenitors. PLoS One. 2008;3(10):e3559, http://dx.doi.org/10.1371/journal.pone.0003559. http://dx.doi.org/10.1371/journal.pone.0...
)
|
SCID mice |
Male |
N/A |
N/A |
|
x |
Navarro-Alvarez N, et al. 2008 (4141. Navarro-Alvarez N, Rivas-Carrillo JD, Soto-Gutierrez A, Yuasa T, Okitsu T, Noguchi H, et al. Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell Transplant. 2008;17(1-2):111–9, http://dx.doi.org/10.3727/000000008783907125. http://dx.doi.org/10.3727/00000000878390...
)
|
SCID mice |
Male |
10-12 weeks |
Streptozotocin 200 mg/kg |
x |
|
Pearson T, et al. 2008 (2424. Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, et al. A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008;51(8):1449–56, http://dx.doi.org/10.1007/s00125-008-1057-1. http://dx.doi.org/10.1007/s00125-008-105...
)
|
NOD-SCID mice |
N/A |
N/A |
Streptozotocin 150 mg/kg |
|
x |
Vlad G, et al. 2008 (2525. Vlad G, D’Agati VD, Zhang QY, Liu Z, Ho EK, Mohanakumar T, et al. Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice. Diabetes. 2008;57(7):1878–86, http://dx.doi.org/10.2337/db08-0054. http://dx.doi.org/10.2337/db08-0054...
)
|
NOD-SCID mice |
Female |
6-10 weeks |
Streptozotocin 180 mg/kg |
x |
|
Papas KK, et al. 2007 (4242. Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE 3rd, et al. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007;7(3):707–13, http://dx.doi.org/10.1111/j.1600-6143.2006.01655.x. http://dx.doi.org/10.1111/j.1600-6143.20...
)
|
N/A |
N/A |
N/A |
Streptozotocin (dose: N/A) |
|
x |
Fornoni A, et al. 2007 (2626. Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, et al. Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia. 2008;51(2):298–308, http://dx.doi.org/10.1007/s00125-007-0889-4. http://dx.doi.org/10.1007/s00125-007-088...
)
|
NU/NU mice |
N/A |
N/A |
Streptozotocin 200 mg/kg |
|
x |
Biancone L, et al. 2007 (4343. Biancone L, Crich SG, Cantaluppi V, Romanazzi GM, Russo S, Scalabrino E, et al. Magnetic resonance imaging of gadolinium-labeled pancreatic islets for experimental transplantation. NMR Biomed. 2007;20(1):40–8, http://dx.doi.org/10.1002/nbm.1088. http://dx.doi.org/10.1002/nbm.1088...
)
|
BALB/c mice |
Female |
6-8 weeks |
N/A |
|
x |
Gao R, et al. 2006 (4444. Gao R, Ustinov J, Korsgren O, Mikkola M, Lundin K, Otonkoski T. Maturation of in vitro-generated human islets after transplantation in nude mice. Mol Cell Endocrinol. 2007;264(1-2):28–34, http://dx.doi.org/10.1016/j.mce.2006.10.007. http://dx.doi.org/10.1016/j.mce.2006.10....
)
|
BALB/c mice |
Male |
6-8 weeks |
N/A |
|
x |
Cantaluppi V, et al. 2006 (4545. Cantaluppi V, Biancone L, Romanazzi GM, Figliolini F, Beltramo S, Ninniri MS, et al. Antiangiogenic and immunomodulatory effects of rapamycin on islet endothelium: relevance for islet transplantation. Am J Transplant. 2006;6(11):2601–11, http://dx.doi.org/10.1111/j.1600-6143.2006.01534.x. http://dx.doi.org/10.1111/j.1600-6143.20...
)
|
SCID and C57BI/6 mice |
N/A |
N/A |
N/A |
|
x |
Sabek OM, et al. 2006 (4646. Sabek OM, Marshall DR, Penmetsa R, Scarborough O, Gaber AO. Examination of gene expression profile of functional human pancreatic islets after 2-week culture. Transplant Proc. 2006;38(10):3678–9, http://dx.doi.org/10.1016/j.transproceed.2006.10.117. http://dx.doi.org/10.1016/j.transproceed...
)
|
NOD-SCID mice |
N/A |
N/A |
Glucose 2 g/kg |
|
x |
Lu Y, et al. 2006 (4747. Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, et al. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006;14(6):851–6, http://dx.doi.org/10.1016/j.ymthe.2006.08.007. http://dx.doi.org/10.1016/j.ymthe.2006.0...
)
|
NOD-SCID mice |
Male |
8-12 weeks |
streptozotocin 160 mg/kg |
x |
|
Fraker C, et al. 2006 (4848. Fraker C, Timmins MR, Guarino RD, Haaland PD, Ichii H, Molano D, et al. The use of the BD oxygen biosensor system to assess isolated human islets of langerhans: oxygen consumption as a potential measure of islet potency. Cell Transplant. 2006;15(8-9):745–58, http://dx.doi.org/10.3727/000000006783981440. http://dx.doi.org/10.3727/00000000678398...
)
|
NU/NU mice |
Male |
N/A |
Streptozotocin 200 mg/kg |
x |
|
Paulsson JF, et al. 2006 (4949. Paulsson JF, Andersson A, Westermark P, Westermark GT. Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. Diabetologia. 2006;49(6):1237–46, http://dx.doi.org/10.1007/s00125-006-0206-7. http://dx.doi.org/10.1007/s00125-006-020...
)
|
N/A |
Male |
N/A |
N/A |
|
x |
Päth G, et al. 2006 (5050. Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, Limbert C, et al. Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo. Am J Physiol Endocrinol Metab. 2006;291(6):E1168–76, http://dx.doi.org/10.1152/ajpendo.00436.2005. http://dx.doi.org/10.1152/ajpendo.00436....
)
|
C57BL/6 mice |
N/A |
8-10 weeks |
Streptozotocin (dose: N/A) |
x |
|