Rats |
Intraperitoneal |
LD50 = 210 mg/kg |
EPSTEIN et al. (1939)EPSTEIN, S.; THRONDSON, W.D.; TAINTER, M.L. Possible deleterious effects of using soap substitutes in dentifrices. The Journal of the American Dental Association, v.26, n.1, p.1461-1471, 1939.
|
5 and 10% in water for 5 days |
100% lethality |
EPSTEIN et al. (1939)EPSTEIN, S.; THRONDSON, W.D.; TAINTER, M.L. Possible deleterious effects of using soap substitutes in dentifrices. The Journal of the American Dental Association, v.26, n.1, p.1461-1471, 1939.
|
2 and 4% in feed for 4 months |
No reaction and growth reduction, respectively. |
FITZHUGH; NELSON (1948)FITZHUGH, O.G.; NELSON, A.A. Chronic oral toxicities of surface-active agents. Journal of the American Pharmacists Association, v.37, n.1, p.29-32, 1948.
|
Intravenous |
LD50 = 188 mg/kg |
CASCORBI et al. (1963)CASCORBI, H.F.; RUDO, F.G.; LU, G.G. Acute toxicity of intravenous sodium lauryl sulfate. Journal of Pharmacological Sciences, v.52, n.8, p.803-805, 1963. https://doi.org/10.1002/jps.2600520822
https://doi.org/10.1002/jps.2600520822...
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Acute oral Repeated doses |
LD501 = 1200 mg/kg |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
(oral hepatotoxicity) |
NOAEL2 = 100 mg/kg/day |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
Guinea pigs |
Acute dermal |
LD50 => 1200 mg/kg |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
Rabbits and mouse |
Toxicity for development/teratogenicity |
NOAEL ≤ 300 mg/kg/day (maternal toxicity) |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
NOAEL = 600 mg/kg/day (fetal malformation) |
Rabbits |
Acute dermal toxicity |
LD50 = 600 mg/kg |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
Mouse |
Intraperitoneal |
LD50 = 250 mg/kg |
GALE; SCOTT (1953)GALE, L.E.; SCOTT, P.M. A pharmacological study of a homologous series of sodium alkyl sulfates. Journal of the American Pharmacists Association. v.42, n.5, p.283-287, 1953.
|
Oral |
LD50 = 2700 mg/kg |
GLOXHUBER (1972)GLOXHUBER, C.H. Toxicology of basic materials in washing and cleaning agents. Fette, Seifen, Anstrichmittel, v.74, n.1, p.49-57, 1972. https://doi.org/10.1002/lipi.19720740110
https://doi.org/10.1002/lipi.19720740110...
|
Reproductive route (male fertility) |
NOAEL = 1000 mg/kg/day |
UNEP (1997)UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). SIDS initial assessment report. Sodium dodecyl sulfate (CAS No. 151- 21-3). In Screening Information Data Sheet (SIDS) for High Volume Chemicals. v.4. Pt. 2. Geneva: UNEP/OECD/UN/IRPTC, 1997. p.1-39.
|
Dogs |
Oral: 135 mg/kg/day for 10 months |
No reaction |
FOGELSON; SHOCH (1944)FOGELSON, S.J.; SHOCH, D.E. Treatment of gastroduodenal ulcerative disease with sodium alkyl sulfate. Archives of Internal Medicine, v.73, n.3, p.212-216, 1944. https://doi.org/10.1001/archinte.1944.00210150015003
https://doi.org/10.1001/archinte.1944.00...
|
Goat kids |
Oral: 0.5% in milk |
Apathy and light diarrhea in 7 days of treatment |
SOUSA (2016)SOUSA, A.L.M. Utilização do dodecil sulfato de sódio (SDS) no leite e colostro como inativador químico do vírus da Artrite Encefalite Caprina. 2016. 96f. Dissertation (Master’s degree in Zootechnics) – Universidade Estadual Vale Do Acaraú, Sobral, 2016.
|
|
Oral: 1% in milk |
Apathy, severe diarrhea and death in 72 hours of treatment |
SOUSA (2016)SOUSA, A.L.M. Utilização do dodecil sulfato de sódio (SDS) no leite e colostro como inativador químico do vírus da Artrite Encefalite Caprina. 2016. 96f. Dissertation (Master’s degree in Zootechnics) – Universidade Estadual Vale Do Acaraú, Sobral, 2016.
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