Cemil, et al. (2012)13
|
Aged Garlic Extract |
Antioxidant proprieties, molecular mechanism uncertain |
250 mg/kg |
Oral |
24 hour |
Inclinated Plane Test, Histology |
Kotil, et al. (2006)14
|
Agmatine |
Inhibits enzime iNOS |
50 mg/kg ou 100mg/kg |
Intraperitoneal |
5 minutes |
Tarlov Neurological Scale, Inclinated Plane Test |
Toklu, et al. (2010)15
|
Alpha-Lipoic Acid |
Co-factor for several mitochondrial dehydrogenases, participates in redox reactions. |
50 mg/kg |
Intraperitoneal |
30 minutes |
Gale Motor Fuctional Scale, Histology |
Sayin, et al. (2013)16
|
Alpha-Lipoic Acid |
50, 100, 150, 200 mg/kg |
Intraperitoneal |
Immediately |
BBB†, Inclinated Plane Test, Histology |
Al Jadid, et al. (2009)17
|
Alpha-Tocopherol |
Endogenous antioxidant and reduces lipid peroxidation and generation of free radicals |
1000mg/kg and 2000mg/kg |
Oral |
Not Specified |
Behavior Test |
Asirvatham, et al. (2012)18
|
Alpha-Tocopherol |
2,000 mg/kg |
Intraperitoneal |
Not Specified |
BBB† |
Soy, et al. (2004)19
|
Aminoguanidine |
High-potency iNOS inhibitor |
100mg/kg |
Intraperitoneal |
Immediately |
Inclinated Plane Test, Tarlov Neurological Scale, Histology |
Moon, et al. (2012)20
|
Angelica Dahuricae |
Inhibits LPS- induced expression of inflammatory mediators such as NO, inducible nitric oxide synthase (iNOS), COX-2, and TNF-alpha in macrophages by inhibiting MAPKsand IkB/NF-kB signal pathways. |
100mg/kg |
Oral |
2 hour |
Inclinated Plane Test, Foot Print Test, Histology |
Kim, et al. (2011)21
|
Anthocyanin |
As antioxidant efects, inhibit inflammation, as a scavenger of active oxygen species |
400 mg/kg |
Via NG-tube |
Not Specified |
BBB†, Histology |
Zhang, et al. (2014)22
|
Apigenin |
Anti-oxidant through inhibition of NADPH-oxidase enzyme |
10 mg/kg and 20 mg/kg |
Intraperitoneal |
Immediately |
BBB† |
Impellizzeri, et al. (2011)23
|
Apocynin |
5mg/kg 10% DMSO |
Intraperitoneal |
1 hour |
Neurological Examination, Histology |
Yan, et al. (2014)24
|
Ascorbic Acid |
Free Radical Scavenger |
100mg/kg 200mg/kg |
Intraperitoneal |
1 hour |
BBB†, Foot Print Test, Histology |
Wang, et al. (2014)25
|
Curcumin |
Inhibition of NF-kB and JAK2/STAT3 pathways, decreases levels of IL-1 e NO. |
50mg/kg |
Intraperitoneal |
Not Specified |
BMS Scale, Histology |
Kim, et al. (2014) 26
|
Curcumin |
200mg/kg |
Intraperitoneal |
Not Specified |
BBB†, Histology |
Kalayci, et al. (2005)27
|
Ebselen |
Glutatione-related mechanism, still uncertain |
10mg/kg |
Intraperitoneal |
Immediately |
Inclinated Plane Test, Neurological Examination, Histology |
Ozgiray, et al. (2011)28
|
Edaverone |
Inhibitory effect on lipid peroxidation by scavenging free radicals, and it prevents vascular endothelial cell injury |
3 mg/kg |
Intraperitoneal |
1 hour |
Tarlov Neurological Scale |
Wang, et al. (2013)29
|
Edaverone |
5mg/kg |
Intraperitoneal |
5 minutes |
BBB†, Histology |
Otha, et al. (2005)30
|
Edaverone |
5mg/kg |
Endovenous |
5 minutes |
BBB†, Histology |
Khalatbary, et al. (2009) 31
|
Epigallocatechin Gallate |
Act in inflammation and apoptosis, uncert |
50/kg |
Intraperitoneal |
Immediately |
Behavior Test, Histology |
Tian, et al. (2013)32
|
Epigallocatechin Gallate |
20mg/kg |
Intrathecal |
Immediately |
BBB†, Histology |
Genovese, et al. (2007)33
|
Melatonin |
Free radical scavenger, stimules catalase, SOD, GSH- reductase, peroxidase. Decreases lipid peroxidation. |
10mg/kg |
Intraperitoneal |
1 hour |
BBB†, Histology |
Schiaveto-de-Souza, et al. (2013)34
|
Melatonin |
2.5mg/kg |
Intraperitoneal |
5 min prior SCI and 1h after |
BBB† |
Park, et al. (2012)35
|
Melatonin |
10 mg/kg |
Subcutaneous |
24 hour |
BBB† |
Gul, et al. (2005)36
|
Melatonin |
50mg/kg; 100mg/kg |
Intraperitoneal |
Immediately |
Inclinated Plane Test, Neurological Examination, Histology |
Genovese, et al (2005)37
|
Melatonin |
50mg/kg |
Intraperitoneal |
30 minutes |
Tarlov Neurological Scale, Histology |
Cayli, et al. (2004)38
|
Melatonin |
10mg/kg |
Intraperitoneal |
Immediately |
Gale Motor Fuctional Scale, Eletrophysiology |
Fujimoto, et al. (2000)39
|
Melatonin |
2,5mg/kg |
Intraperitoneal |
5 minutes |
Tarlov Neurological Scale, Inclinated Plane Test, Histology |
Fee, et al. (2010)40
|
Melatonin Analogue |
10mg/kg and 100mg/kg |
Intraperitoneal |
15 minutes |
Behavior Test, Histology |
Liu, et. Al. (2013)41
|
Mn (III) Tetrakis |
Potentializes SOD activity and scavengers ROS |
4 mg/kg |
Intrathecal |
Immediately |
BBB†, Histology |
Hillard, et al. (2004)42
|
Tempol |
Stimulate SOD catalytic activity, also inhibits hydroxyl radical generation by oxidizing transition metals necessary for Haber-Weiss/Fenton reactions. |
69mg/kg, 138mg/kg, 275mg/kg, 550mg/kg |
Intraperitoneal |
20 minutes |
BBB†, Histology |
Ling, et al. (2013)43
|
Mn (III) Tetrakis |
Potentializes SOD activity and scavengers ROS |
10mg/kg |
Intraperitoneal |
1 hour |
Histology |
Cavus, et al. (2014)44
|
Montelukast |
Leukotrien receptor antago- nist that specifically inhibites sodium cisteinyl leukotrien CysLT1 receptor, diminishing inflammatory process |
5mg/kg |
Intraperitoneal |
Immediately |
Tarlov Neurological Scale, Histology |
Kanter, et al. (2006)45
|
Nigella Sativa |
Anti-inflammatory, immunomodulatory |
0,2ml/kg |
Intraperitoneal |
Immediately |
Inclinated Plane Test, Neurological Examination, Histology |
Assis, et al. (2014)46
|
Proantrocyanidin |
Stimulates SOD, inhibits NDMA glutamate receptors |
10/mg/kg |
Intraperitoneal |
1 hour |
BBB†, Grip Force Test |
Schultke, et al. (2010)47
|
Quercitin |
Scavenger, decreases lipid peroxidation |
25mmol/kg |
Intraperitoneal |
1 hour |
BBB†, Histology |
Song, et al. (2013)48
|
Quercitin |
0,2mg/kg |
Intraperitoneal |
1 hour |
BBB†, Histology |
Schultke, et al. (2003)49
|
Quercitin |
5, 25, 50, 100 mmol/kg |
Intraperitoneal |
1 hour |
BBB†, Histology |
Genovese, et al. (2006)50
|
Quercitin |
30mg/kg |
Oral |
1 hour |
BBB†, Histology |
Ates, et al. (2006)51
|
Resveratrol |
Anti-oxidation effect, suppression of immunoreactivity, reduction of inflammatory cytokines including IL-1β, IL-10, TNF-α, and myeloperoxidase, inhibition of injury-induced apoptosis |
100mg/kg |
Intraperitoneal |
24h |
Motor Function Score, Inclinated Plane Test, Histology |
Liu, et. Al. (2011)52
|
Resveratrol |
200mg/kg |
Intraperitoneal |
Not Specified |
BBB†, Behavior Test,Locomotor Rating Scale, Histology |
Yune, et al. (2009)53
|
Scutellaria Baicalensis |
Inhibition lipopolysaccharide-induced expression and anti-inflammatory proprieties |
30, 100, or 300 mg/kg |
Oral |
2 hour |
BBB†, Footprint Test, Histology |
Sharma, et al. (2006)54
|
Sintetic (H-29051) |
Melatonin Analogue |
50mg/kg |
Via NG-tube |
10 minutes |
Inclinated Plane Test, Histology |
Serarslan, et al. (2010)55
|
Tadalafil |
Aa selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 |
2 mg/kg |
Via NG-tube |
Immediately |
Neurological Examination |