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vol.18 issue3PRELIMINARY RESULTS OF VERTEBRAL CANAL DECOMPRESSION BY SPINOUS PROCESS SPLITTINGSURGERY FOR ADULT SPINAL SCOLIOSIS: DO THE BENEFITS OUTWEIGH THE RISKS? author indexsubject indexarticles search
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Coluna/Columna

Print version ISSN 1808-1851On-line version ISSN 2177-014X

Abstract

TELES FILHO, RICARDO VIEIRA et al. GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW. Coluna/Columna [online]. 2019, vol.18, n.3, pp.236-239.  Epub Sep 02, 2019. ISSN 2177-014X.  https://doi.org/10.1590/s1808-185120191803212974.

The idiopathic scoliosis (IS) is the most common form of spinal deformity. The pathogenesis of IS is still poorly understood. Several studies show evidence that the genetic component is determinant to the development of IS. In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. Level of evidence III; Narrative Review.

Keywords : Adolescent; Scoliosis; Spine; Genetics; Polymorphism, Genetic.

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