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Brazilian Journal of Otorhinolaryngology

Print version ISSN 1808-8694


ESQUENAZI, David; BUSSOLOTI FILHO, Ivo; CARVALHO, Maria da Gloria da Costa  and  BARROS, Fernando Souza de. The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR. Braz. j. otorhinolaryngol. (Impr.) [online]. 2010, vol.76, n.1, pp.78-84. ISSN 1808-8694.

The human papillomavirus (HPV) is a DNA virus, which belongs to papillomaviridae family, being of low and high risk, which infect the skin and mucous membranes and can induce benign and malign tumor formation. In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia. AIM: to study the frequency of HPV finding in oral mucosa of normal people. MATERIALS AND METHODS: Prospective study, cross-sectional cohort. One hundred volunteers, young adults, healthy, aged between 20 and 31 years, university students with no history, no complains, without oral or oropharyngeal lesions. They were submitted to a questionnaire with questions regarding HPV infection epidemiology. The samples were harvested by brushing and analyzed by PCR. RESULTS: The results were negative for HPV in all samples. CONCLUSION: It seems we had high social and economical class individuals, with nutrition rich in carotenoyds and vitamin C, low smoking and alcohol consumption and heterosexual habits with predominant monogamy and regular use of condoms.

Keywords : mouth; papillomavirus infections; mouth mucosa.

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