Brazilian Journal of Otorhinolaryngology
versión impresa ISSN 1808-8694
PORTES, Karla Palma et al. Influence of selant fibrin on the wound healing of the pigs vocal folds. Braz. j. otorhinolaryngol. [online]. 2012, vol.78, n.1, pp. 51-56. ISSN 1808-8694. http://dx.doi.org/10.1590/S1808-86942012000100008.
Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space. AIM: To evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation. MATERIALS AND METHODS: This was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out. RESULTS: The side on which glue was applied had an average of 27.8% against 20.4% of the side without glue. CONCLUSION: The collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue.
Palabras llave : fibrin tissue adhesive; vocal cords; wound healing.