Abstract

FINKLER, Andréa Dulor; SILVEIRA, Aron Ferreira da; MUNARO, Gisiane  and  ZANROSSO, Crisley Dossin. Otoprotection in guinea pigs exposed to pesticides and ginkgo biloba. Braz. j. otorhinolaryngol. [online]. 2012, vol.78, n.3, pp. 122-128. ISSN 1808-8694.  http://dx.doi.org/10.1590/S1808-86942012000300020.

Pesticides are widely used in agriculture, despite the risk of hearing loss related to the exposure to their chemical components. This study looks into protective drugs to counteract the ototoxicity of pesticides. OBJECTIVE: This study aims to analyze the effect ginkgo biloba extract may have in protecting against possible cochlear damage caused by organophosphate pesticides (methamidophos). Anatomic changes are assessed through surface and electron microscopy. MATERIALS AND METHODS: This is a prospective experimental study. Twenty-one guinea pigs were given saline solution, pesticide, and ginkgo biloba alone or combined for seven consecutive days. Then their cochleas were removed and examined in a scanning electron microscope. RESULTS: Pesticide-exposed guinea pigs had morphological alterations in their cochleas and injuries in the three turns analyzed through electron microscopy. Injury intensity varied according to the dosages of the agents given to the test subjects. Guinea pigs treated with pesticide and ginkgo biloba maintained the architecture of their outer hair cells in all cochlear turns. CONCLUSION: The antioxidant properties found in the ginkgo biloba extract protected guinea pigs from pesticide ototoxicity.

Keywords : cytoprotection; toxicity; ginkgo biloba; organophosphorus compounds.