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International Archives of Otorhinolaryngology

versão impressa ISSN 1809-9777versão On-line ISSN 1809-4864

Resumo

BENTO, Ricardo Ferreira et al. Mandibular Branch of the Facial Nerve in Wistar Rats: New Experimental Model to Assess Facial Nerve Regeneration. Int. Arch. Otorhinolaryngol. [online]. 2014, vol.18, n.3, pp.277-282. ISSN 1809-9777.  http://dx.doi.org/10.1055/s-0034-1366977.

Introduction

 The ideal animal model for nerve regeneration studies is the object of controversy, because all models described by the literature have advantages and disadvantages.

Objective

 To describe the histologic and functional patterns of the mandibular branch of the facial nerve of Wistar rats to create a new experimental model of facial nerve regeneration.

Methods

 Forty-two male rats were submitted to a nerve conduction test of the mandibular branch to obtain the compound muscle action potential. Twelve of these rats had the mandibular branch surgically removed and submitted to histologic analysis (number, partial density, and axonal diameter) of the proximal and distal segments.

Results

 There was no statistically significant difference in the functional and histologic variables studied.

Conclusion

 These new histologic and functional standards of the mandibular branch of the facial nerve of rats establish an objective, easy, and greatly reproducible model for future facial nerve regeneration studies.

Palavras-chave : facial nerve; electromyography; nerve regeneration; histologic analysis.

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