Ryu et al1616 Ryu EW, Lee HY, Lee SY, Park MS, Yeo SG. Clinical manifestations and prognosis of patients with Ramsay Hunt syndrome. Am J Otolaryngol 2012;33(3):313-318
|
155 |
HB III – 24 |
HB I or II – 22 |
Prednisolone (80 mg oral methylprednisolone per day for 4 days, 60 mg/d for 2 days, 40 mg/d for 2 days, 20 mg/d for 2 days, and 10 mg/d for 5 days);Acyclovir (4000 mg/d for 7 days) |
3 months |
91 (58.7%) |
HB IV – 53 |
HB I or II – 35 |
HB V or VI – 78 |
HB I or II – 34 |
Zainine et al44 Zainine R, Sellami M, Charfeddine A, Beltaief N, Sahtout S, Besbes G. Ramsay Hunt syndrome. Eur Ann Otorhinolaryngol Head Neck Dis. Head and Neck Dis 2012;129:22-25
|
15 |
HB III – 1 |
HB I – 1 |
Hydrocortisone (100 mg 3x/day IV for 8 days)Acyclovir (4000 mg/d PO for 8 days) |
8 months |
10 (66.6%) |
HB IV – 8 |
HB I – 4HB II – 2HB III – 1HB IV – 1 |
HB V – 6 |
HB II – 3HB V – 3 |
Kansu et al1212 Kansu L, Yilmaz I. Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. Int J Pediatr Otorhinolaryngol 2012;76(6):772-776
|
01 |
HB V – 1 |
HB IV – 1 |
Corticosteroid (1 mg/kg/d)Acyclovir (90 mg/kg/d) |
4 months |
00 (0%) |
Donati et al22 Donati D, De Santi L, Ginanneschi F, Cerase A, Annunziata P. Successful response of non-recovering Ramsay Hunt syndrome to intravenous high dose methylprednisolone. J Neurol Sci 2012 ; 318(1-2):160-162
|
01 |
HB V – 1 |
HB I – 1 |
Oral valacyclovir (3 g/day, lowered to 1.5 g/day after1 week) and prednisone 50 mg/day.On day 66–methylprednisolone (1 g/day I.V. for 5 days. |
248 days |
02 (100%) |
01 |
HB V – 1 |
HB I – 1 |
Oral acyclovir (800 mg/day) for10 days and prednisone 75 mg/d.On day 37–methylprednisolone, 1 g/day I.V. for 3 days |
73 days |
– |
Shim et al1717 Shim HJ, Jung H, Park DC, Lee JH, Yeo SG. Ramsay Hunt syndrome with multicranial nerve involvement. Acta Otolaryngol 2011 ; 131(2):210-215
|
339 |
HB II – 40 |
HB I – 33HB II – 7 |
Prednisone (1 mg/kg/d orally for 4 days, tapered to zero until day 10)Acyclovir (400 mg/8h for 5 days) |
6 months |
225 (66.3%) |
HB III – 95 |
HB I – 52HB II – 34HB III – 9 |
HB IV – 137 |
HB I – 30HB II – 52HB III – 26HB IV – 29 |
HB V – 67 |
HB I- 12HB II – 5HB III – 21HB IV – 13HB V – 16 |
Kim et al1313 Kim YH, Chang MY, Jung HH, et al. Prognosis of Ramsay Hunt syndrome presenting as cranial polyneuropathy. Laryngoscope 2010;120(11):2270-2276
|
11 |
HB II – 5 |
HB I – 5 |
Steroids (40 to 60 mg of prednisolone, or 48 mg of methylprednisolone, orally, for 10 to 37 daysAcyclovir (750 to 4800 mg, intravenously, for 5 to 12 days) |
6 months |
09 (81.8%) |
HB III – 1 |
HB II – 1 |
HB IV – 2 |
HB II – 2 |
HB V – 3 |
HB II – 1HB III – 2 |
Boemo et al11 Boemo RL, Navarrete ML, García-Arumí AM, Copa SL, Graterol D, Scherdel EP. Ramsay Hunt syndrome: our experience. Acta Otorrinolaringol Esp 2010;61(6):418-421
|
54 |
HB II – 4 |
HB I – 4 |
Acyclovir 250 mg/8h and methylprednisolone 120 mg/d IV for 48h; then acyclovir 850 mg/8h for 10 days and methylprednisolone 30mg/d orally, in a decreasing dosage for 16 days |
6 months |
33 (61.1%) |
HB III – 8 |
HB I – 8 |
HB IV – 20 |
HB I – 10HB III – 8HB IV – 2 |
HB V – 22 |
HB I – 3HB II – 8HB III – 6HB IV – 5 |
Gondivkar et al88 Gondivkar S, Parikh V, Parikh R. Herpes zoster oticus: A rare clinical entity. Contemp Clin Dent 2010;1(2):127-129
|
01 |
HB V – 1 |
HB I – 1 |
Initial dose of acyclovir and steroids I.V., and a 2-week course of oral acyclovir and steroids after discharge;Transcutaneal electrical nerve stimulation and facial neuromuscular exercise. |
5 weeks |
01 (100%) |
Yeo et al66 Yeo SW, Lee DH, Jun BC, Chang KH, Park YS. Analysis of prognostic factors in Bell's palsy and Ramsay Hunt syndrome. Auris Nasus Larynx 2007;34(2):159-164
|
26 |
HB II – 3 |
HB I – 2HB II – 1 |
Prednisolone (1 mg/kg/d IV for 5 days; then, the dose was tapered for another 5 days);Acyclovir (5 mg/kg/8h IV for 5 days);Famciclovir (500 mg orally for 7 days, after the 5-day cycle of acyclovir);Dextran;Peripheral vasodilators. |
6 months |
22 (84.6%) |
HB III – 13 |
HB I – 7HB II – 4HB III – 2 |
HB IV – 10 |
HB I – 4HB II – 4HB III – 1HB IV – 1 |
Furuta et al77 Furuta Y, Aizawa H, Ohtani F, Sawa H, Fukuda S. Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome. Ann Otol Rhinol Laryngol 2004;113(9):700-705
|
37 |
HB II – 1 |
HB I – 1 |
Acyclovir (4000 mg in tablet form or 750 mg per day by infusion) or valacyclovir (3000 mg in tablets) was administered to all patients for 5 to 7 days.Patients with grade IV to VI facial paralysis were usually given 40 to 60 mg prednisone for 4 days. |
6 months |
27 (72.9%) |
HB III – 3 |
HB I – 3 |
HB IV – 9 |
HB I – 9 |
HB V – 17 |
HB I – 9HB II – 2HB III – 5HB IV – 1 |
HB VI – 7 |
HB I – 2HB II – 1HB III – 1HB IV – 3 |
Uri et al1111 Uri N, Greenberg E, Kitzes-Cohen R, Doweck I. Acyclovir in the treatment of Ramsay Hunt syndrome. Otolaryngol Head Neck Surg 2003;129(4):379-381
|
23 |
HB IV – 3 |
HB I – 2HB III – 1 |
Acyclovir (5 mg/kg/8h intravenously for 7 days)Hydrocortisone (100 mg/8h intravenously for 7 days) |
1 year |
19 (82.6%) |
HB V – 2 |
HB I – 2 |
HB VI – 18 |
HB I – 11HB II – 4HB III – 1HB IV – 1HB V – 1 |
Kinishi et al1414 Kinishi M, Amatsu M, Mohri M, Saito M, Hasegawa T, Hasegawa S. Acyclovir improves recovery rate of facial nerve palsy in Ramsay Hunt syndrome. Auris Nasus Larynx 2001;28(3):223-226
|
91 |
HB III – 2 |
HB I – 82 |
Dextran (500 mL, for 7 days)Methylprednisolone (500 m on day 1, 250 mg on days 2 and 3 and 100 mg for 4 days thereafterAdenosine triphosphate (ATP) and vitamins B6 and B12Acyclovir, 4000 mg/d, 7 days |
6 months |
85 (93.4%) |
HB IV – 17 |
HB II – 3 |
HB V – 33 |
HB III – 5 |
HB VI – 39 |
HB IV – 1 |
47 |
HB III – 2 |
HB I – 30 |
The same protocol described above, but without the acyclovir |
32 (68%) |
HB IV – 9 |
HB II – 2 |
HB V – 17 |
HB III – 10 |
HB VI – 19 |
HB IV – 5 |
Murakami et al1515 Murakami S, Hato N, Horiuchi J, Honda N, Gyo K, Yanagihara N. Treatment of Ramsay Hunt syndrome with acyclovir-prednisone: significance of early diagnosis and treatment. Ann Neurol 1997 ; 41(3):353-357
|
80 |
HB III – 1 |
HB I – 1 |
Prednisone (1 mg/kg/d, orally or intravenously for 5 days; then, tapered to zero over the following 10 days);Acyclovir (250 mg/8h for 7 days intravenously or 800 mg 5 times/d orally, for 7 days) |
1 year |
65 (81.25%) |
HB IV – 21 |
HB I – 17HB II – 2HB III – 2 |
HB V – 38 |
HB I – 20HB II – 12HB III – 5HB IV – 1 |
HB VI – 20 |
HB I – 4HB II – 9HB III – 7 |
Total
|
882
|
–
|
–
|
–
|
–
|
621 (70.4%)
|