Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence

Serrao, Valéria Trunkl; Brucki, Sônia Maria Dozzi; Campanholo, Kenia Repiso; Mansur, Letícia Lessa; Nitrini, Ricardo; Miotto, Eliane Correa

doi:10.1590/1980-57642015DN93000009

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Dementia & Neuropsychologia

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Original Articles • Dement. neuropsychol. 9 (3) • Jul-Sep 2015 • https://doi.org/10.1590/1980-57642015DN93000009 copy

Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence

DESEMPENHO DE UMA AMOSTRA DE PACIENTES COM COMPROMETIMENTO COGNITIVO LEVE (CCL), DOENÇA DE ALZHEIMER (DA) E IDOSOS SAUDÁVEIS EM TESTE DE DECISÃO LEXICAL (TDL) COMO MEDIDA DE QI PRÉ-MÓRBIDO

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

The objective of this study was to describe the performance of healthy elderly patients with aging-related pathologies (MCI) and patients with AD on a lexical decision test.

Methods:

The study included 38 healthy elderly subjects, 61 MCI and 26 AD patients from the Neurology Department of the Hospital das Clinicas, Behavioral and Cognitive Neurology Group. The neuropsychological instruments included the episodic memory test (RAVLT), subtests from the WAIS-III (Matrix Reasoning and Vocabulary) to determine estimated IQ, the Boston naming test (BNT) and Lexical Decision Test (LDT).

Results:

All groups differed on the MMSE, as expected according to their pathologies, memory tests, naming and estimated IQ. For the vocabulary and the LDT - measures of crystalized intelligence no differences were found.

Conclusion:

The LDT demonstrated that lexical decision can be used as a measure of pre-morbid IQ among the individuals assessed in a Brazilian sample.

pre-morbid IQ; language; Alzheimer's disease

Variable	Control M (SD)	MCI M (SD)	AD M (SD)	P¹
Age	67.37 (5.89)	68.92 (6.49)	75.27 (5.89)	<0.001*
Schooling (years)	11.89 (5.07)	9.8 (5.38)	9.58 (4.68)	0.077
MMSE	27.88 (0.62)	26.03 (0.44)	24.34 (0.57)	<0.001*
GDS15	1.83 (0.46)	2.28 (0.33)	2.94 (0.42)	0.211
PFAQ	0.34 (0.79)	1.18 (0.57)	8.41 (0.72)	<0.001*
Katz	6 (0.09)	6.02 (0.07)	5.66 (0.08)	0.003*

Variable	Control M (SD)	MCI M (SD)	AD M (SD)	P¹	P*	P*	P*
Variable	Control M (SD)	MCI M (SD)	AD M (SD)	P¹	Control × MCI	Control × AD	MCI × AD
RAVLT – Immediate recall (A1 to A5)	46.55 (2.11)	38.35 (1.52)	25.45 (1.94)	<0.001	0.006	<0.001	<0.001
Delayed Recall (A7)	9.53 (0.68)	6.79 (0.49)	2.69 (0.62)	<0.001	0.004	<0.001	<0.001
REC	14.56 (0.54)	13.04 (0.39)	10.48 (0.52)	<0.001	0.067	<0.001	<0.001
BNT	52.84 (1.54)	49.55 (1.1)	46.44 (1.41)	0.012	0.237	0.009	0.234

Variable	Control M (SD)	MCI M (SD)	AD M (SD)	P¹	P*	P*	P*
Variable	Control M (SD)	MCI M (SD)	AD M (SD)	P¹	Control × MCI	Control × AD	MCI × AD
Vocabulary	43.09 (2.4)	38.59 (1.72)	41.96 (2.2)	0.230	0.351	>0.999	0.637
Matrix reasoning	13.12 (0.99)	8.93 (0.71)	9.83 (0.91)	0.003	0.002	0.054	>0.999
IQ	108.9 (2.46)	99.82 (1.77)	102.89 (2.26)	0.012	0.009	0.239	0.831
ldt	52.48 (1.2)	49.84 (0.86)	48.96 (1.1)	0.091	0.200	0.095	>0.999
% correct on LDT	87.46 (1.99)	83.07 (1.43)	81.58 (1.83)	0.089	0.200	0.092	>0.999

Factor	Coefficient	Standard error	t-Value	P	R²
Constant	–17.55	23.71	–0.74	0.464	0.663
60-word LDT	2.21	0.50	4.466	<0.001
Schooling (years of study)	0.96	0.34	2.831	0.008

Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br

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[1] Eliane Correa Miotto. Department of Neurology / Hospital das Clinicas / University of São Paulo - Av. Dr Enéas de Carvalho Aguiar 155 - 05403-000 São Paulo SP - Brazil. E-mail: ecmiotto@usp.br