SciELO - Scientific Electronic Library Online

vol.11 issue2Planning ability impairments in probable Alzheimer's disease patients: Evidence from the Tower of London testSundown syndrome and symptoms of anxiety and depression in hospitalized elderly author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Dementia & Neuropsychologia

Print version ISSN 1980-5764On-line version ISSN 1980-5764


MALAK, Ana Lara Soares Blum et al. Symptoms of depression in patients with mild cognitive impairment in Parkinson's disease. Dement. neuropsychol. [online]. 2017, vol.11, n.2, pp.145-153. ISSN 1980-5764.


To investigate the most frequent depressive symptoms and their association with cognition in Parkinson's disease (PD) patients with mild cognitive impairment (MCI).


48 patients with PD and 44 controls (CG), aged between 50 and 80 years and with at least 4 years of formal education, all with MCI and none diagnosed with depression, were assessed. Patients and controls were matched for age, education, and Mini-Mental State Examination (MMSE) score. Participants underwent clinical evaluation with a neurologist followed by neuropsychological assessment employing the instruments: MMSE, Clock Drawing Test, Verbal Fluency Test (semantic and phonemic), Figures Memory Test (FMT), Stroop Test, Trail Making Test, Digit Span (WAIS III), Rey Auditory Verbal Learning Test (RAVLT), Hooper Visual Organization Test, and Beck Depression Inventory (BDI).


The most frequent depressive symptoms in the PD group were: difficulty working, fatigue and sleep disorders (the latter also being present in CG). BDI score correlated negatively with learning and recognition memory in both groups. Episodic memory, evaluated by the FMT and RAVLT tests, was the cognitive function showing greatest impairment.


Some of the depressive symptoms observed in PD patients with MCI seem to be attributable to complications of PD, while others are common to both PD and MCI, making differential diagnoses complex but crucial.

Keywords : Parkinson's disease; depression; cognition; mild cognitive impairment.

        · abstract in Portuguese     · text in English     · English ( pdf )