SciELO - Scientific Electronic Library Online

 
vol.11 número4EVOLUÇÃO DO DESEMPENHO EM TESTES COGNITIVOS BREVES DE PACIENTES COM ACIDENTE VASCULAR CEREBRAL COM COMPROMETIMENTO COGNITIVO VASCULAR E DEMÊNCIA VASCULAR: AVALIAÇÃO INICIAL E ACOMPANHAMENTOA HIPERTENSÃO, O DIABETES E A OBESIDADE ESTÃO ASSOCIADOS AO MENOR DESEMPENHO COGNITIVO EM IDOSOS RESIDENTES NA COMUNIDADE: DADOS DO ESTUDO FIBRA índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Dementia & Neuropsychologia

versão impressa ISSN 1980-5764versão On-line ISSN 1980-5764

Resumo

MUELA, Henrique Cotchi Simbo et al. Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance. Dement. neuropsychol. [online]. 2017, vol.11, n.4, pp.389-397. ISSN 1980-5764.  https://doi.org/10.1590/1980-57642016dn11-040008.

Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall.

Objective:

To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension.

Methods:

211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological (NPE) tests were used to determine cognitive function. Pulse wave velocity was measured using the Complior®. Carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. Middle cerebral artery flow velocity was measured by transcranial Doppler ultrasonography.

Results:

Both arterial stiffness parameters and cerebral vasoreactivity worsened in line with HTN severity. There was a negative correlation between breath holding index (BHI) and arterial stiffness parameters. Cognitive performance worsened in line with HTN severity, with statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE and MoCA. The same tendency was observed on the NPE tests.

Conclusion:

Hypertension severity was associated with higher AS, worse BHI, and lower cognitive performance.

Palavras-chave : hypertension; vascular changes; arterial stiffness; cerebral blood flow; cognitive performance.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )