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RGO - Revista Gaúcha de Odontologia

versão impressa ISSN 0103-6971versão On-line ISSN 1981-8637

Resumo

FRANCO, Mayra Moura et al. Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease. RGO, Rev. Gaúch. Odontol. [online]. 2015, vol.63, n.4, pp.432-438. ISSN 0103-6971.  http://dx.doi.org/10.1590/1981-863720150003000093063.

Objective:

To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis.

Methods:

Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -g was quantified by ELISA.

Results:

The production of IL-4, IL-10, IL-17 and INF-g was higher on group D when compared to other groups (p <0.05), which in turn were similar (p ³0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p³0.05).

Conclusion:

Were observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.

Palavras-chave : Chronic periodontitis; Cytokines; Diabetes Mellitus; Inflammation.

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