SciELO - Scientific Electronic Library Online

 
vol.67Investigação dos fatores psicológicos associados à língua fissuradaAnálise do sistema de referência e contrarreferência da Endodontia em um município da região metropolitana de Belo Horizonte, Minas Gerais, Brasil índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


RGO - Revista Gaúcha de Odontologia

versão impressa ISSN 1981-8637versão On-line ISSN 1981-8637

Resumo

MONTEIRO, Larissa Cavalcanti et al. Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B. RGO, Rev. Gaúch. Odontol. [online]. 2019, vol.67, e20190018.  Epub 06-Maio-2019. ISSN 1981-8637.  http://dx.doi.org/10.1590/1981-86372019000183558.

Objective:

The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B.

Methods:

This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected from40 individuals diagnosed with ALL and from40 healthy subjects, as a comparative group, matched by age and gender with ALL group. The mean age for both groups were 8 years-old. The isolation and identification of the Candidaspecies were performed using the CHROMagarCandidaTM and confirmed by polymerase chain reaction. The samples were subjected to antifungal susceptibility by microdilution assay for nystatin and amphotericin B. Salivary alterations and chemotherapy-induced oralmucositis were evaluated using modifiedOral Assessment Guide.

Results:

The positivity to Candida was higher inALL individuals (32.5%,13/40)than in a comparative group(2.5%, 1/40) (p<0.001). Candida albicans was the most prevalent strain (86.6%). The mucositis was directly associated with positive Candidacolonization (p=0.017) in the ALL group but not related with salivary alterations (p= 0.479). Six strains of C. albicans (54.5%), on ALL group, were resistant to nystatin and all strains were not susceptible to amphotericin B.

Conclusion:

Candida colonization was associated with ALL condition and with oral mucositis in these individuals. C. albicans was the prevalent strain and most samples were resistant to antifungal agents tested, nystatin and amphotericin B.

Palavras-chave : Candida; Precursor cell lymphoblastic leukemia-lymphoma; Prevalence.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )