Gene therapy and its applicability in Dentistry

Terapia gênica e sua aplicabilidade na Odontologia

ABSTRACT

Objective

Explore scientific publications on the use of gene therapy in dentistry.

Methods

A bibliographic survey was carried out with articles published in the last eleven years, available on online platforms that had the highest correlation to the proposed theme.

Results

Since the 1960s, researchers have attempted to establish guidelines for treatments using gene therapy; however, it was only in the mid-1990s that their use in science was authorized. Gene therapy in dentistry has the ability to alter and improve genetically, through stem cells in dental tissues associated with recombinant viral vectors, therapeutic protocols against diseases that do notrespond to conventional treatments.

Conclusion

The perspectives of dentistry concerning this resource have been positive, mainly in the reestablishment and regeneration of tissues in pulp pathologies, periodontopathies, bone disorders, orofacial pain among others. It is known that this form of therapy still requires more research, however, in the near future, it may be a safe first option treatment in hospital and outpatient settings.

Indexing terms
Dental Care; Dentistry; Genetic therapy