Psychology & Neuroscience
On-line version ISSN 1983-3288
GALVAO, Bruno de Oliveira; GOMES, Vitor de Castro; MAISONNETTE, Silvia and LANDEIRA- FERNANDEZ, J.. Panic-like behaviors in Carioca High-and Low-conditioned Freezing rats. Psychol. Neurosci. [online]. 2011, vol.4, n.2, pp.205-210. ISSN 1983-3288. http://dx.doi.org/10.3922/j.psns.2011.2.005.
Panic disorder involves both recurrent unexpected panic attacks and persistent concern about having additional attacks. Electrical stimulation of the dorsal periaqueductal gray (dPAG) is an animal model of both panic attack and panic disorder, whereas contextual fear conditioning represents a model of anticipatory anxiety. Previous research indicated that anxiety has an inhibitory effect on panic attack-like behavior. However, still unclear is the role that anticipatory anxiety plays in panic disorder-like behaviors. This issue was investigated with two lines of animals selectively bred for high (Carioca High-Freezing) and low (Carioca Low-Freezing) freezing in response to contextual cues associated with footshock. The results suggest that although anticipatory anxiety might exert an inhibitory effect on the expression of panic attack, it might also facilitate the pathogenesis of panic disorder.
Keywords : breeding lines; dorsal periaqueductal gray; contextual fear conditioning; freezing behavior; escape behavior; panic attack; panic disorder.