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Revista Bioética

versão impressa ISSN 1983-8042versão On-line ISSN 1983-8034


FREGNANI, José Humberto Tavares Guerreiro et al. Ethics of the use of placebos in clinical research: a proposal for decision-making algorithms. Rev. Bioét. [online]. 2015, vol.23, n.3, pp.456-467. ISSN 1983-8042.

The use of placebos in clinical research has been a matter of considerable debate in recent years, notably when the World Medical Association published, in 2002, a note of clarification for paragraph 29 of the Helsinki Declaration. Brazil is known for its strong opposition to the flexible use of placebos. Both the Federal Council of Medicine and the National Health Council have published resolutions regulating the use of placebos in Brazil, preventing their use if there is a more effective therapeutic method already in place. The present study reinforces that position and aims to describe the various uses of placebos in clinical research, as well as examining the complex decisions relating to the ethics of their use. Additionally, the authors propose a reflection on the use of placebos through decision-making algorithms based on Brazilian ethical standards.

Palavras-chave : Placebos; Control groups; Bioethics; Biomedical research; Helsinki Declaration; Methods; Decision support techniques.

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