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Revista Brasileira de Parasitologia Veterinária

On-line version ISSN 1984-2961

Abstract

GUEDES, Paulo Marcos Matta et al. Hematological alterations during experimental canine infection by Trypanosoma cruzi. Rev. Bras. Parasitol. Vet. [online]. 2012, vol.21, n.2, pp. 151-156. ISSN 1984-2961.  http://dx.doi.org/10.1590/S1984-29612012000200015.

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.

Keywords : Trypanosoma cruzi; Beagle dogs; parasitemia; lymphocytosis; anemia; leukocytosis.

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