Almazán et al. (2010)Almazán C, Lagunes R, Villar M, Canales M, Rosario-Cruz R, Jongejan
F, et al. Identification and characterization of Rhipicephalus (Boophilus)
microplus candidate protective antigens for the control of cattle tick
infestations. Parasitol Res 2010; 106(2): 471-479.
http://dx.doi.org/10.1007/s00436-009-1689-1 http://dx.doi.org/10.1007/s00436-009-168...
|
R.(B.) microplus
|
4 |
Bm86 |
Adjuvant + Saline |
European crossbred |
Montanide ISA 50 V |
3 |
IM |
0.1 |
0 |
12 |
100 [1-(CRT×CR0×CRF)] |
60% |
Andreotti et al. (2002)Andreotti R, Gomes A, Malavazi-Piza KC, Sasaki SD, Sampaio CAM,
Tanaka AS. BmTI antigens induce a bovine protective immune response against
Boophilus microplus tick. Int Immunopharmacol 2002; 2(4): 557-563.
http://dx.doi.org/10.1016/S1567-5769(01)00203-X http://dx.doi.org/10.1016/S1567-5769(01)...
|
R. (B.)microplus
|
8 |
0 |
Carrier |
Nellore |
Freund's |
3 |
SC |
0.1 |
150 |
6 |
100 [1-(CRT×CRW×CR0)] |
72.80% |
Andreotti et al. (2012)Andreotti R, Cunha RC, Soares MA, Guerrero FD, Leite FPL, De León
AP. Protective immunity against tick infestation in cattle vaccinated with
recombinant trypsin inhibitor of Rhipicephalus microplus. Vaccine 2012; 30(47):
6678-3385. http://dx.doi.org/10.1016/j.vaccine.2012.08.066 http://dx.doi.org/10.1016/j.vaccine.2012...
|
R. (B.) microplus
|
6 |
0 |
Adjuvant + Saline |
Crossbred |
Montanide ISA 61 VG |
3 |
0 |
0.1 |
0 |
12 |
101 [1-(CRT×CR0×CRF)] |
32% |
Andreotti (2006) |
R. (B.) microplus
|
16 and 8 |
0 |
Unvaccinated |
Crossbred |
Gavac and TickGard |
2 |
SC |
0.1 |
140 - 170 |
8 |
100 [1-(CRT×CRO×CRF)] |
49.20% |
Andreotti (2007)Andreotti R. A synthetic bmti n-terminal fragment as antigen in
bovine immunoprotection against the tick Boophilus microplus in a pen trial. Exp
Parasitol 2007; 116(1): 66-70.
http://dx.doi.org/10.1016/j.exppara.2006.11.009 http://dx.doi.org/10.1016/j.exppara.2006...
|
R. (B.) microplus
|
8 |
0 |
Adjuvant |
Nellore x Simmental |
Saponin in water |
3 |
IM |
0.1 |
140 - 170 |
8 |
100 [1-(CRT×CRO×CRF)] |
18.40% |
Azhahianambi et al.
(2009a)Azhahianambi P, De La Fuente J, Suryanarayana VVS, Ghosh S. Cloning,
expression and immunoprotective efficacy of rHaa86, the homologue of the Bm86
tick vaccine antigen, from Hyalomma anatolicum anatolicum. Parasite Immunol
2009a; 31(3): 111-122.
http://dx.doi.org/10.1111/j.1365-3024.2008.01082.x http://dx.doi.org/10.1111/j.1365-3024.20...
|
H. a. anatolicum
|
5 and 3 |
Saponin |
PBS |
Crossbred |
Saponin in mineral oil |
3 |
IM |
0.125 |
0 |
10 - 12 |
100 [1-(CRT×CRO)] |
61.60% |
Azhahianambi et al. (2009b) |
H. a. anatolicum
|
5 |
0 |
Adjuvant |
Crossbred |
10% Montanide 888 in mineral oil |
3 |
IM |
0.4 and 0.1 |
0 |
7 |
100 [1-(CRT×CRO)] |
72% |
Canales et al. (1997)Canales M, Enríquez A, Ramos E, Cabrera D, Dandie H, Soto A, et al.
Large-scale production in Pichia pastoris of the recombinant vaccine Gavac
against cattle tick. Vaccine 1997; 15(4):414-422.
http://dx.doi.org/10.1016/S0264-410X(96)00192-2 http://dx.doi.org/10.1016/S0264-410X(96)...
|
R.(B.) microplus
|
NC |
NC |
NC |
Holstein and Crossbred |
Montanide 888 in mineral oil |
3 |
0 |
0.1 |
0 |
0 |
100 [1-(CRT×CR0×CRF)] |
91% |
Canales et al. (2009)Canales M, Labruna MB, Soares JF, Prudencio CR, De La Fuente J.
Protective efficacy of bacterial membranes containing surface-exposed BM95
antigenic peptides for the control of cattle tick infestations. Vaccine 2009;
27(52): 7244-7248.
http://dx.doi.org/10.1016/j.vaccine.2009.09.123 http://dx.doi.org/10.1016/j.vaccine.2009...
|
R. (B.) microplus and R.
annulatus
|
5 |
Gavac |
Adjuvant + Saline |
Crossbred |
Montanide ISA 50 V |
3 |
IM |
0.1 |
0 |
0 |
100 [1-(CRT×CR0×CRF)] |
99.60% |
Cunha et al. (2012)Cunha R, León AP, De Leite F, Pinto LDS, Santos A Jr, Andreotti R.
Bovine immunoprotection against Rhipicephalus (Boophilus) microplus with
recombinant Bm86-Campo Grande antigen. Rev Bras Parasitol Vet 2012; 21(3):
254-262. http://dx.doi.org/10.1590/S1984-29612012000300014 http://dx.doi.org/10.1590/S1984-29612012...
|
R. (B.) microplus
|
6 |
0 |
Adjuvant + Saline |
Crossbred |
Montanide ISA 61 VG |
3 |
IM |
0.1 |
0 |
12 |
101 [1-(CRT×CR0×CRF)] |
31% |
De La Fuente et al. (2010) |
A. americanum
|
3 |
0 |
Adjuvant + Saline |
Crossbred |
Montanide ISA 50 V |
3 |
SC |
0.1 |
0 |
0 |
100 [1-(CRT×CR0×CRF)] |
66% |
Fragoso et al. (1998)Fragoso H, Rad PH, Ortiz M, Rodríguez M, Redondo M, Herrera L, et
al. Protection against Boophilus annulatus infestations in cattle vaccinated
with the B. microplus Bm86-containing vaccine Gavac. Vaccine 1998; 16(20):
1990-1992. http://dx.doi.org/10.1016/S0264-410X(98)00116-9 http://dx.doi.org/10.1016/S0264-410X(98)...
|
R. annulatus
|
NC |
0 |
Unvaccinated |
Aberdin Angus and Crossbred |
Gavac |
3 |
IM |
0.1 |
1 |
0 |
100 [1-(CRT×CR0×CRF)] |
99.99% |
Galaï et al. (2012)Galaï Y, Canales M, Saïd MB, Gharbi M, Mhadhbi M, Jedidi
M, et al. Efficacy of Hyalomma scupense (Hd86) antigen against Hyalomma
excavatum and H. scupense tick infestations in cattle. Vaccine 2012; 30(49):
7084-7089. http://dx.doi.org/10.1016/j.vaccine.2012.09.051 http://dx.doi.org/10.1016/j.vaccine.2012...
|
H. scupense and H. excavatum
|
5 |
Bm86 |
Adjuvant |
Holstein |
Montanide 887 |
3 + 1 |
IM |
0.1 |
0 |
3 - 4 |
100 [1 - (CRT×CRO)] |
67.40% |
García-García et al.
(2000)García-García JC, Montero C, Redondo M, Vargas M, Canales M, Boué O,
et al. Control of ticks resistant to immunization with Bm86 in cattle vaccinated
with the recombinant antigen Bm95 isolated from the cattle tick, Boophilus
microplus. Vaccine 2000; 18(21): 2275-2287.
http://dx.doi.org/10.1016/S0264-410X(99)00548-4 http://dx.doi.org/10.1016/S0264-410X(99)...
|
R. (B.) microplus
|
3 |
Gavac |
Adjuvant |
Holstein |
Montanide 888 |
3 |
IM |
0.1 |
0 |
12 |
100 [1-(CRT×CR0×CRF)] |
89% |
Hajdusek et al. (2010)Hajdusek O, Almazán C, Loosova G, Villar M, Canales M, Grubhoffer L,
et al. Characterization of ferritin 2 for the control of tick infestations.
Vaccine 2010; 28(17): 2993-2998.
http://dx.doi.org/10.1016/j.vaccine.2010.02.008 http://dx.doi.org/10.1016/j.vaccine.2010...
|
R. (B.) microplus, R.
annulatus and Ixodes ricinus
|
4 |
Bm86 |
Adjuvant + Saline |
Crossbred |
Montanide ISA 50 V |
3 |
IM |
0.1 |
0 |
0 |
100 [1-(CRT×CR0×CRF)] |
100% |
Jeyabal et al. (2010)Jeyabal L, Azhahianambi P, Susitha K, Ray DD, Chaudhuri P,
Vanlahmuaka, et al. Efficacy of rHaa86, an orthologue of Bm86, against challenge
infestations of Hyalomma anatolicum anatolicum. Transbound Emerg Dis v 2010;
27(1-2): 96-102.
http://dx.doi.org/10.1111/j.1865-1682.2010.01107.x http://dx.doi.org/10.1111/j.1865-1682.20...
|
H. a. anatolicum
|
5 |
0 |
Adjuvant |
0 |
Montanide 888 in mineral oil |
3 |
SC |
0.4 |
0 |
7 |
100 [1 - (CRT×CRO)] |
82.30% |
Kumar et al. (2009)Kumar A, Garg R, Yadav CL, Vatsya S, Kumar RR, Sugumar P, et al.
Immune responses against recombinant tick antigen, Bm95, for the control of
Rhipicephalus (Boophilus) microplus ticks in cattle. Vet Parasitol 2009;
165(1-2): 119-124.
http://dx.doi.org/10.1016/j.vetpar.2009.06.030 http://dx.doi.org/10.1016/j.vetpar.2009....
|
R. (B.) microplus
|
6 |
0 |
Unvaccinated |
Crossbred |
Algel |
4 |
SC |
0.2 |
0 |
6 |
100 [1-(CRT×CR0×CRF)] |
81.27% |
Kumar et al. (2012a)Kumar B, Azhahianambi P, Ray DD, Chaudhuri P, De La Fuente J, Kumar
R, et al. Comparative efficacy of rHaa86 and rBm86 against Hyalomma anatolicum
anatolicum and Rhipicephalus (Boophilus) microplus. Parasite Immunol 2012a;
34(6): 297-301.
http://dx.doi.org/10.1111/j.1365-3024.2012.01356.x http://dx.doi.org/10.1111/j.1365-3024.20...
|
R. (B.) microplus and H. a.
anatolicum
|
5 |
Gavac |
PBS |
European crossbred |
10% Montanide 888 in mineral oil |
3 |
IM |
0.1 |
0 |
10 - 12 |
101 [1 - (CRT×CRO)] |
45.80% |
Kumar et al. (2012b)Kumar B, Murugan K, Ray DD, Ghosh S. Efficacy of rBm86 against
Rhipicephalus (Boophilus) microplus (IVRI-I line) and Hyalomma anatolicum
anatolicum (IVRI-II line) infestations on bovine calves. Parasitol Res 2012b;
111(2): 629-635. http://dx.doi.org/10.1007/s00436-012-2879-9 http://dx.doi.org/10.1007/s00436-012-287...
|
R. (B.) microplus and H. a.
anatolicum
|
2 of 5 |
0 |
PBS |
Crossbred |
Gavac |
3 |
IM |
0.1 |
0 |
6 - 8 |
102 [1 - (CRT×CRO)] |
44.50% |
Merino et al. (2011)Merino O, Almazán C, Canales M, Villar M, Moreno-Cid JA,
Estrada-Peña A, et al. Control of Rhipicephalus (Boophilus) microplus
infestations by the combination of subolesin vaccination and tick autocidal
control after subolesin gene knockdown in ticks fed on cattle. Vaccine 2011;
29(12): 2248-2254.
http://dx.doi.org/10.1016/j.vaccine.2011.01.050 http://dx.doi.org/10.1016/j.vaccine.2011...
|
R.(B.) microplus
|
6 |
0 |
Adjuvant + Saline |
European crossbred |
Montanide ISA 50 V |
3 |
IM |
0.1 |
0 |
7 |
100 [1-(CRT×CR0)] |
75% |
Miller et al. (2012)Miller R, Estrada-Peña A, Almazán C, Allen A, Jory L, Yeater
K, et al. Exploring the use of an anti-tick vaccine as a tool for the integrated
eradication of the cattle fever tick, Rhipicephalus (Boophilus) annulatus.
Vaccine 2012; 30(38): 5682-5687.
http://dx.doi.org/10.1016/j.vaccine.2012.05.061 http://dx.doi.org/10.1016/j.vaccine.2012...
|
R. annulatus
|
5 |
0 |
Adjuvant |
Angus |
Gavac |
4 |
IM |
0.1 |
136 - 227 |
0 |
100 [1-(CRT×CR0×CRF)] |
99.90% |
Parizi et al. (2011)Parizi LF, Utiumi KU, Imamura S, Onuma M, Ohashi K, Masuda A, et al.
Cross immunity with Haemaphysalis longicornis glutathione S-transferase reduces
an experimental Rhipicephalus (Boophilus) microplus infestation. Exp Parasitol
2011; 127(1): 113-118.
http://dx.doi.org/10.1016/j.exppara.2010.07.001 http://dx.doi.org/10.1016/j.exppara.2010...
|
R. (B.) microplus
|
4 and 3 |
0 |
PBS + Adjuvant |
Hereford |
Montanide 888, Marcol 52 and Saponin |
6 |
IM |
0.2 and 0.4 |
0 |
0 |
100 [1-(CRT×CR0×CRF)] |
57% |
Patarroyo et al. (2002) |
R. (B.) microplus
|
4 |
0 |
Adjuvant or Water |
Crossbred |
Saponin in water |
3 |
SC |
2 |
0 |
8 - 10 |
100 [1-(CRT×CR0×CRF)] |
81.05% |
Sugumar et al. (2011)Sugumar P, Chandran D, Sudha Rani G, Shahana PV, Maske DK,
Rangarajan PN, et al. Recombinant mid gut antigen (Bm95) as a vaccine against
Indian Rhiphicephalus haemaphysaloides in Bos indicus cattle. Res Vet Sci 2011;
90(2): 262-268. http://dx.doi.org/10.1016/j.rvsc.2010.05.037 http://dx.doi.org/10.1016/j.rvsc.2010.05...
|
R. haemaphysaloides
|
3 |
0 |
PBS |
Crossbred |
Aluminum hydroxide gel |
2 |
SC |
0.2 |
0 |
6 |
100 [1-(CRT×CR0×CRF)] |
78.90% |
Wong and Opdebeeck (1989) |
R.(B.) microplus
|
4 |
0 |
Adjuvant |
Hereford |
Saponin Quil A |
2 |
IM |
0.016 - 0.5 |
0 |
9 - 12 |
100 [1-(CR0)] |
96% |