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Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790

Abstract

MORENO, Andréia de Haro; SILVA, Maria Fernanda Conz da  and  SALGADO, Hérida Regina Nunes. Stability study of azithromycin in ophthalmic preparations. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.2, pp.219-226. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502009000200005.

A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 µg/mL. The study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).

Keywords : Azithromycin [stability study]; Bioassay; Photodegradation; Ophthalmic preparations.

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