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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790

Resumo

KAUSHIK, Darpan et al. Anticonvulsant activity of Bacopa monniera in rodents. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.643-649. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502009000400006.

Bacopa monnieri (L), belonging to the Scrophulariaceae family and commonly known as Brahmi, is well known in India for its CNS activity but its neuropharmacological effect has not yet been explored. In the present study, the antiepileptic effects of the plant were investigated. The ethanolic extract of Bacopa monniera was tested for anticonvulsant activity in albino rats, using different convulsive models. The ethanolic extract of leaves produced significant anticonvulsant activity for all the different models studied. The present study shows a probable mechanism of action similar to that of benzodiazepines (GABA agonist). Thus, these results emphasize the need to diversify by using alternative therapeutic approaches pertaining to herbal medicine, where a single easily available plant may provide solutions to several therapeutic challenges, as observed in the anticonvulsant action of ethanolic extract of B. monniera.

Palavras-chave : Bacopa monniera [pharmacognosy]; Anticonvulsant; MES test; PTZ model; Hypoxia model; Strychnine model.

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