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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790

Resumo

CESAR, Isabela da Costa  e  PIANETTI, Gerson Antônio. Quantitation of artemether in pharmaceutical raw material and injections by high performance liquid chromatography. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.737-742. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502009000400018.

The quantitation of artemether in both pharmaceutical raw material and injections was carried out by high performance liquid chromatography (HPLC) with ultraviolet detection. A Zorbax C18 column (150 x 4.6 mm; 5 μm), at 30 °C, and a mobile phase composed of acetonitrile and water (70:30), at a flow rate of 1ml/min, were used. The detection wavelength was 216 nm and the injection volume was 20 μL. The method proved to be linear (r2=0.9999), precise (RSD < 20% for intra-day and inter-day precision), accurate and selective regarding possible impurities and excipients of the samples. The detection and quantitation limits were 8 μg/mL and 25 μg/mL, respectively. The artemether content obtained in the raw material analysis was 99.26% and in the injections, 102.08%. The optimized and validated method may be successfully employed to perform routine quality control analyses.

Palavras-chave : Artemether [quantitation]; High performance liquid chromatography [quantitative analysis]; Antimalarials.

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